Optimization of interneuron function by direct coupling of cell migration and axonal targeting
| Autor: | Alfredo Llorca, Lynette Lim, Martijn Selten, Janelle M.P. Pakan, Andre Marques-Smith, Nathalie L. Rochefort, Sung Eun Bae, Oscar Marín |
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| Přispěvatelé: | European Commission, European Research Council, Simons Foundation, EMBO, Wellcome Trust, Royal Society (UK) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Interneuron genetics [MafB Transcription Factor] MafB Transcription Factor physiology [Interneurons] Biology Inhibitory postsynaptic potential Article cytology [Cerebral Cortex] 03 medical and health sciences 0302 clinical medicine physiology [Cerebral Cortex] cytology [GABAergic Neurons] Cell Movement Interneurons ddc:570 medicine Animals Mafb protein mouse GABAergic Neurons Axon physiology [GABAergic Neurons] Cerebral Cortex physiology [Axons] Mice Knockout General Neuroscience Cell migration Marginal zone Embryonic stem cell Axons 030104 developmental biology medicine.anatomical_structure nervous system Cerebral cortex physiology [Cell Movement] Neuroscience cytology [Interneurons] 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Nature reviews / Neuroscience 21(7), 920-931 (2018). doi:10.1038/s41593-018-0162-9 Nature neuroscience Lim, L, Pakan, J M P, Selten, M M, Marques-Smith, A, Llorca, A, Bae, S E, Rochefort, N L & Marín, O 2018, ' Optimization of interneuron function by direct coupling of cell migration and axonal targeting ', Nature neuroscience . https://doi.org/10.1038/s41593-018-0162-9 Lim, L, Pakan, J M P, Selten, M M, Marques-Smith, A, Llorca, A, Bae, S E, Rochefort, N L & Marín, O 2018, ' Optimization of interneuron function by direct coupling of cell migration and axonal targeting ', Nature Neuroscience, vol. 21, pp. 920–931 . https://doi.org/10.1038/s41593-018-0162-9 |
| DOI: | 10.1038/s41593-018-0162-9 |
| Popis: | Neural circuit assembly relies on the precise synchronization of developmental processes, such as cell migration and axon targeting, but the cell-autonomous mechanisms coordinating these events remain largely unknown. Here we found that different classes of interneurons use distinct routes of migration to reach the embryonic cerebral cortex. Somatostatin-expressing interneurons that migrate through the marginal zone develop into Martinotti cells, one of the most distinctive classes of cortical interneurons. For these cells, migration through the marginal zone is linked to the development of their characteristic layer 1 axonal arborization. Altering the normal migratory route of Martinotti cells by conditional deletion of Mafb—a gene that is preferentially expressed by these cells—cell-autonomously disrupts axonal development and impairs the function of these cells in vivo. Our results suggest that migration and axon targeting programs are coupled to optimize the assembly of inhibitory circuits in the cerebral cortex. This work was supported by a grant from the European Research Council (ERC-2011-AdG 293683) to O.M., Marie Curie Actions of the European Union’s FP7 program (MC-CIG 631770) to N.R. and (IEF 624461) J.P., and funds from the Shirley Foundation, Patrick Wild Center, RS MacDonald Charitable Trust, and Simons Initiative for the Developing Brain to N.R. L.L. was the recipient of an EMBO long-term postdoctoral fellowship. N.R. is supported by a Sir Henry Dale Fellowship from the Wellcome Trust and the Royal Society (102857/Z/13/Z). |
| Databáze: | OpenAIRE |
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