MR Imaging of Hepatic Injury in the LEC Rat under a High Magnetic Field (7.05T)
| Autor: | Taketoshi Asanuma, Mikinori Kuwabara, Yaasuhiro Kon, Shigezou Shimokawa, Keizo Yamamoto, Yoshiko Hirano |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Rats Inbred LEC Hepatitis General Veterinary Chemistry business.industry Hepatitis Animal medicine.disease Magnetic Resonance Imaging Mr imaging Rats Hepatolenticular Degeneration Liver Chronic hepatitis T2 relaxation medicine Animals Protons Rats Wistar Mr images Human hepatitis Nuclear medicine business High magnetic field Acute hepatitis |
| Zdroj: | Journal of Veterinary Medical Science. 61:239-244 |
| ISSN: | 1347-7439 0916-7250 |
| DOI: | 10.1292/jvms.61.239 |
| Popis: | Visualization of copper-induced hepatitis (CuH) in LEC rats was performed by using an MRI apparatus equipped with a magnet producing a high magnetic field of 7.05 T. When three groups of LEC rats (6-16 [pre-hepatitis], 15-26 [acute hepatitis] and 40-77 [chronic hepatitis] weeks old) were examined by MRI under T2-weighted imaging conditions which are suitable for the diagnosis of human hepatitis, hypointense MR images of the livers were, as a whole, obtained in all groups, suggesting that these conditions were not adequate for imaging of CuH of LEC rats. The shortening of the T1 and T2 relaxation times of livers due to an excess amount of paramagnetic irons under the high magnetic field was responsible for the lowering of MR signal intensities of the livers, especially those of 15 to 26-week old rats showing acute hepatitis. However, theoretical calculation of the MR signal intensities using the T1 and T2 relaxation times of the livers indicated that their imaging might be possible under proton density-weighted conditions even with a high magnetic field. Experimental results showed that hepatic injury was visualized as hyperintense regions in the MR image of the liver in the acute-phase rat. |
| Databáze: | OpenAIRE |
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