Association of White Matter Hyperintensity Progression with Cognitive Decline in Patients with Amnestic Mild Cognitive Impairment

Autor: Raita Fukasawa, Hirofumi Sakurai, Tomohiko Sato, Takahiko Umahara, Kentaro Hirao, Fumio Yamashita, Soichiro Shimizu, Haruo Hanyu, Hidekazu Kanetaka, Rieko Haime, Akito Tsugawa
Rok vydání: 2021
Předmět:
Male
medicine.medical_specialty
Deep white matter hyperintensities
Fluid-attenuated inversion recovery
Neuropsychological Tests
behavioral disciplines and activities
03 medical and health sciences
0302 clinical medicine
Cognition
mild cognitive impairment
030502 gerontology
Alzheimer Disease
Internal medicine
mental disorders
medicine
periventricular hyperintensities
Semantic memory
Verbal fluency test
Humans
Cognitive Dysfunction
Cognitive decline
Association (psychology)
Aged
business.industry
General Neuroscience
General Medicine
Mental Status and Dementia Tests
Magnetic Resonance Imaging
White Matter
Hyperintensity
Psychiatry and Mental health
Clinical Psychology
Frontal lobe
Cardiology
Disease Progression
Female
Geriatrics and Gerontology
0305 other medical science
business
030217 neurology & neurosurgery
Research Article
Zdroj: Journal of Alzheimer's Disease
ISSN: 1875-8908
Popis: Background: White matter hyperintensities (WMH) on MRI have been reported to increase the risk of conversion from mild cognitive impairment (MCI) to Alzheimer’s disease (AD). However, effects of the progression of WMH on the cognition of patients with MCI remains unclear to date. Objective: To investigate the association between WMH progression and cognitive decline in amnestic MCI patients. Methods: Thirty-eight subjects with amnestic MCI were analyzed prospectively every year for 2 years. Fourteen MCI subjects dropped out on the final visit, and therefore 24 subjects with MCI were analyzed for the entire duration. The volumes of periventricular hyperintensities (PVH) and deep WMH (DWMH) were measured on T2 FLAIR using the 3D-slicer. The associations between PVH/DWMH progression and cognitive decline were investigated. Results: An increase in DWMH volume significantly correlated with changes in Mini-Mental State Examination and category verbal fluency scores, whereas an increase in PVH volume did not correlate with changes in any item. Conclusion: DWMH progression was closely associated with a decline in frontal lobe function and semantic memory, suggesting that WMH progression might affect some AD pathophysiologies in amnestic MCI patients.
Databáze: OpenAIRE
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