Assessment and Characterization of Time-related Differences in Plaque Composition by Intravascular Ultrasound–derived Radiofrequency Analysis in Heart Transplant Recipients
| Autor: | Johannes Rieber, Raffaella Matteucci Gothe, Volker Klauss, Uwe Siebert, Andreas König, Bruno Reichart, Thomas M. Schiele, E Kilian, Hae-Young Sohn |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Time Factors Adolescent medicine.medical_treatment Coronary Artery Disease Coronary artery disease Postoperative Complications Intravascular ultrasound medicine Humans Ultrasonography Interventional Coronary atherosclerosis Aged Heart transplantation Transplantation medicine.diagnostic_test business.industry Ultrasound Middle Aged medicine.disease Tunica intima Coronary Vessels Cross-Sectional Studies surgical procedures operative medicine.anatomical_structure Circulatory system Disease Progression cardiovascular system Heart Transplantation Female Surgery Tunica Intima Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Journal of Heart and Lung Transplantation. 27:302-309 |
| ISSN: | 1053-2498 |
| DOI: | 10.1016/j.healun.2007.12.003 |
| Popis: | Background The survival of heart transplant patients is limited by cardiac allograft vasculopathy (CAV). Intravascular ultrasound (IVUS) and IVUS-derived radiofrequency plaque composition analysis (IVUS-RF) provide further information about the process of coronary atherosclerosis. Methods In this study we aimed to assess the time-dependent differences in disease progression in patients with CAV. Fifty-six patients were divided into three groups according to time interval after transplantation (Group I: 1 to 3 months, 18 patients; Group II, 1 to 5 years, 20 patients; Group III: 5 to 15 years, 18 patients). Results IVUS-RF revealed time-dependent increases in all plaque components. The largest increase was shown for fibrotic, fibrofatty and necrotic tissue between Groups I and II. Dense calcium area increased uniformly in all groups. IVUS-RF–derived plaque type analysis revealed predominantly fibrotic plaques in all groups with a decrease of frequency over time. Fibrolipidic and fibrotic–calcific plaques increased uniformly. High-risk lesions, such as thick-cap fibroatheromas (FAs), increased in Groups I and II and decreased in Group III. Thin-cap FAs were detected only in Group III. Conclusions IVUS-RF, as compared with gray-scale IVUS, provides better detailed information about the development of CAV by plaque morphology and composition analysis in different stages after heart transplantation. Serial IVUS-RF analysis in these patients may improve the stratification of heart transplant recipients. |
| Databáze: | OpenAIRE |
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