RMI 15,731 (1-[5-tetradecyloxy-2-furanyl]-ethanone), a new antirhinovirus compound

Autor:	R A Parker, R J Ash, A C Hagan, G D Mayer
Rok vydání:	1979
Předmět:	Pharmacology Rhinovirus Cell Survival Temperature Limiting Biology medicine.disease_cause Antiviral Agents Virology Virus Infectious Diseases Toxicity medicine Humans Pharmacology (medical) Viral shedding Furans Clinical evaluation Volume concentration Intracellular HeLa Cells Research Article
Zdroj:	Antimicrobial Agents and Chemotherapy. 16:301-305
ISSN:	1098-6596 0066-4804
DOI:	10.1128/aac.16.3.301
Popis:	RMI 15,731 (1-[5-tetradecyloxy-2-furanyl]-ethanone) is a new antiviral compound with activity specific for rhinoviruses. Virus synthesis in R-HeLa cells was susceptible to low concentrations (0.25 micrograms/ml) of the compound. RMI 15,731 was effective if added for 1 h before infection and removed or if added as late as 6 h postinfection. Low concentrations of the compound directly inactivated infectious rhinovirus in a time- and temperature-dependent fashion. RMI 15,731 appears to be a promising new antirhinovirus compound for clinical evaluation since it (i) blocks intracellular virus synthesis (without cellular toxicity), and (ii) directly inactivates virions. The last property may be important in limiting virus shedding from an infected host.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21c47cc0199e9ae2110d4b4f02d5e59 https://doi.org/10.1128/aac.16.3.301 Zobrazit plný text záznamu