Reduced cellular toxicity of a new silver-containing antimicrobial dressing and clinical performance in non-healing wounds
| Autor: | J. Ellermann, D. Spaeth, J. Effing, H. Smola, R. Görl, H. Kapp, M. Mappes, K. Ziegler, S. Otten, P. Zoellner |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Silver Physiology Cell Survival Dermatology Microbial Sensitivity Tests Occlusive Dressings Microbiology Cell Line Ointments Bacterial colonization Medicine Humans Healing wounds Cell survival Aged Pharmacology Wound Healing integumentary system Bacteria business.industry Clinical performance General Medicine Antimicrobial Anti-Bacterial Agents Occlusive dressing Toxicity Female Wound healing business |
| Zdroj: | Skin pharmacology and physiology. 19(3) |
| ISSN: | 1660-5527 |
| Popis: | Bacterial colonisation of wounds may delay wound healing. Modern silver-containing dressings are antimicrobial, yet cellular toxicity is a serious side-effect. We provide data for a newly formulated silver-containing oint ment dressing, Atrauman Ag, for antimicrobial activity and cytotoxicity. Atrauman Ag effectively killed a panel of commensal skin as well as pathogenic bacterial strains while cytotoxicity for HaCaT keratinocytes was only around 10%. With these favourable in vitro tests, Atrauman Ag was analysed in 86 patients with traumatic and non-healing wounds of different aetiologies. The wound state was evaluated for 3 subsequent dressing changes. The slough score was reduced from 59.2 to 35.8%, granulation tissue increased from 27 to 40% and epithelialisation went up from 12.1 to 24%. We conclude that Atrauman Ag has a superior profile of antimicrobial activity over cellular toxicity and the low silver ion release rate may prevent interference with wound-healing mechanisms. |
| Databáze: | OpenAIRE |
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