Modeling the bioactive copper(II) complex stability by the use of an experimental design
| Autor: | Janos Canadi, Goran Nikolić, Ivana M. Savic, Ivan M. Savic, Aleksandar Došić, Milorad D. Cakić |
|---|---|
| Jazyk: | srbština |
| Rok vydání: | 2012 |
| Předmět: |
General Chemical Engineering
chemistry.chemical_element Conductivity lcsh:Chemical technology 01 natural sciences Stability (probability) 03 medical and health sciences Hydrolysis chemistry.chemical_compound lcsh:TP1-1185 Thermal stability copper-pullulan complex 030304 developmental biology 0303 health sciences Chromatography 010401 analytical chemistry copper-pullulancomplex Pullulan modeling General Chemistry Factorial experiment stability Copper 0104 chemical sciences chemistry Chemical engineering Degradation (geology) |
| Zdroj: | Hemijska industrija (2012) 66(5):693-699 Hemijska Industrija, Vol 66, Iss 5, Pp 693-699 (2012) |
| ISSN: | 0367-598X |
| Popis: | A new organic-inorganic complex based on copper ions with pullulan polysaccharide can be used for the treatment of copper deficiency in human organism. Therefore, the aim of this paper was to carry out the stress stability study of this potential active substance by the use of mathematical modelling. A full factorial design was successfully applied for the stability studying. The electrical conductivity was taken as the response, while the degradation time, concentration of the oxidative agent, temperature, and pH value were used as the independent variables. All process variables were analyzed at the three levels. On the basis of statistical analysis of data for the thermal stability study, the temperature and degradation time had the main impact on the conductivity of the complex solution. The degradation time had the significant effect in the case of oxidative stability study. In addition to the degradation time, the pH value and the temperature had the significant effect on the complex stability for the hydrolytic stability study. |
| Databáze: | OpenAIRE |
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