Association of diabetes susceptibility gene calpain-10 with pancreatic cancer among smokers
| Autor: | Melissa A. Austin, Sengkeo L. Srinouanprachanh, Margaret T. Mandelson, Pui Yee Fong, Teresa A. Brentnall, Zahra Afsharinejad, Gary E. Goodman, Megan D. Fesinmeyer, Matt J. Barnett, Federico M. Farin, Emily White |
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| Rok vydání: | 2010 |
| Předmět: |
Oncology
Male medicine.medical_specialty genetic structures Genotype medicine.medical_treatment Susceptibility gene Polymorphism Single Nucleotide Article Internal medicine Diabetes mellitus Pancreatic cancer medicine Humans Genetic Predisposition to Disease Aged biology business.industry Calpain Reverse Transcriptase Polymerase Chain Reaction Smoking Gastroenterology Case-control study Middle Aged medicine.disease Radiation therapy Pancreatic Neoplasms Endocrinology Diabetes Mellitus Type 2 Case-Control Studies biology.protein Female business |
| Zdroj: | Journal of gastrointestinal cancer. 41(3) |
| ISSN: | 1941-6636 |
| Popis: | The objective of this study was to test the association between calpain-10 (CAPN10), a diabetes susceptibility gene, with risk of pancreatic cancer (PC).DNA samples from 83 incident exocrine PC cases and 166 controls, all of whom were smokers, were genotyped for four markers of CAPN10 in a nested case-control study based on the Beta-Carotene and Retinol Efficacy Trial (CARET), a randomized chemoprevention trial of subjects at high risk of lung cancer. Controls were matched on sex, race, age, CARET intervention arm, duration of exposure to asbestos, and smoking history. Conditional logistic regression was used for statistical analyses.The minor allele of SNP-43 (rs3792267) in intron 3 was associated with increased risk of PC with an odds ratio of 1.57 (95%CI 1.03-2.38, p = 0.035) per allele. The three markers of the highest risk haplotype had an odds ratio of 1.98 (95%CI 1.12-3.49, p = 0.019) for risk of PC compared to the most common haplotype. There was no evidence of interaction between either of these associations by diabetes status.These results suggest that variation in CAPN10 may be associated with increased risk of PC among smokers. Thus, studies of genes associated with diabetes risk in PC are warranted in a larger population. |
| Databáze: | OpenAIRE |
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