Expression and function of an IgE-binding animal lectin (ϵBP) in mast cells
| Autor: | Luciano G. Frigeri, Riaz I. Zuberi, Fu-Tong Liu, Michael W. Robertson, Daniel K. Hsu, Christine A. Gritzmacher |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Cell type
Galectin 3 Molecular Sequence Data Immunoglobulin E Lectins medicine Animals Amino Acid Sequence Mast Cells Receptor Pharmacology chemistry.chemical_classification Binding Sites Membrane Glycoproteins biology Receptors IgE Glycobiology Macrophages Binding protein Lectin Mast cell Antigens Differentiation Molecular Weight medicine.anatomical_structure Biochemistry chemistry biology.protein Electrophoresis Polyacrylamide Gel Glycoprotein |
| Zdroj: | Immunopharmacology. 26:187-195 |
| ISSN: | 0162-3109 |
| DOI: | 10.1016/0162-3109(93)90034-n |
| Popis: | epsilon BP (IgE-binding protein) is a 31,000 M(r) protein originally identified in rat basophilic leukemia (RBL) cells. The protein is composed of two domains with the amino-terminal domain containing a highly conserved repetitive sequence and the carboxyl-terminal domain containing consensus sequences shared by other beta-galactoside-binding soluble lectins. The protein has wide tissue distribution, is found on cell surfaces and in extracellular milieu. By combined efforts from several research groups including ours a multifunctional nature of this lectin began to emerge. This review emphasizes the following characteristics of epsilon BP: (i) epsilon BP is secreted by cells such as macrophages; (ii) like many other lectins, epsilon BP functions at least bivalently; (iii) epsilon BP has specificity for distinct oligosaccharide structures that have a terminal galactose not masked by sialic acids; and (iv) in addition to binding IgE, epsilon BP binds to surfaces of various cell types via lectin-carbohydrate interaction. Importantly, epsilon BP binds to the IgE receptor on mast cells. We propose that epsilon BP can function as a modulatory protein on various cells by cross-linking critical cell surface glycoproteins. The proposed action of epsilon BP on mast cells is presented as a model. |
| Databáze: | OpenAIRE |
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