Effect of Drug Alprazolam on Restrained Stress Induced Alteration of Serum Cortisol and Antioxidant Vitamins (Vitamin C and E) in Male Albino Rats
| Autor: | Kusal K Das, Rohini Sharanappa Kori, R.H. Aladakatti, S D Desai |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Drug Vitamin medicine.medical_specialty Antioxidant media_common.quotation_subject medicine.medical_treatment Clinical Biochemistry lcsh:Medicine life threatening events 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine anti-anxiety agent Internal medicine medicine Contraindication media_common Vitamin C business.industry lcsh:R General Medicine 030104 developmental biology Endocrinology Alprazolam chemistry Concomitant Anatomy Section business 030217 neurology & neurosurgery Serum cortisol harmful effects medicine.drug |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 10, Iss 8, Pp AF07-AF09 (2016) |
| ISSN: | 2249-782X |
| DOI: | 10.7860/jcdr/2016/21355.8380 |
| Popis: | Introduction Stress can cause harmful effects in the body that induce a wide range of biochemical and behavioural changes. As anti-stress drugs are routinely used to combat stress hence study is needed to assess the contraindication of these drugs in the physiological systems. Aim To investigate the effect of alprazolam on restrained stress induced alteration of serum cortisol, and antioxidant vitamin levels in male albino rats. Materials and methods Adult male albino rats (body weight 175-225g) were divided into four groups of six animals in each. Group I (control), kept undisturbed in the metabolic cage throughout the 42 days experimental period. Group II (stress) rats were kept in a wire mesh restrainer for 6 hr/day for 42 days. Group III (stress+ withdrawal) rats were stressed for 21 days and withdrawal of stress for remaining 21 days (total 42 days). Group IV (stress + alprazolam) rats were only stressed for 21 days and treated with drug alprazolam (5mg/kg body weight, intraperitoneal) in continuation with stress for remaining 21 days (total period is 42 days). At the end of 42 days all the rats were sacrificed and serum cortisol, vitamin C and E levels were estimated. Results Group II (stressed) showed a significant increase in serum cortisol level with concomitant decrease of serum vitamin C and E levels. Group III (withdrawal) and Group IV (+alprazolam) rats showed significant reduction of serum cortisol along with subsequent increase of serum vitamin C and E concentrations. Conclusion Results indicate a possible antioxidant effect of alprazolam on restrained stress induced alteration of serum cortisol and antioxidant vitamin levels. |
| Databáze: | OpenAIRE |
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