High incidence of meningeal leukemia in lymphoid blast crisis of chronic myelogenous leukemia
| Autor: | Gauri Nanjangud, Tapan K. Saikia, Dhabhar Bn, Chandrika N. Nair, Suresh H. Advani, R. S. Iyer, Gopal R, Nadkarni Ks, Subodh Dhond, Muthupandian Ashokkumar |
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| Rok vydání: | 1993 |
| Předmět: |
Pathology
medicine.medical_specialty Time Factors Medullary cavity Gastroenterology Metastasis Central nervous system disease Meninges Leukemic Infiltration hemic and lymphatic diseases Internal medicine Leukemia Myelogenous Chronic BCR-ABL Positive medicine Humans Radiotherapy business.industry Incidence (epidemiology) Incidence Myeloid leukemia Hematology HLA-DR Antigens medicine.disease Survival Analysis Methotrexate Neprilysin Complication business Blast Crisis Meningeal Leukemia Chronic myelogenous leukemia |
| Zdroj: | American journal of hematology. 43(1) |
| ISSN: | 0361-8609 |
| Popis: | Fifteen patients with lymphoid blast crisis of chronic myelogenous leukemia (LyBC-CML) and five patients with acute lymphoblastic leukemia converting to Philadelphia-positive (Ph+) chronic myeloid leukemia (ALL Ph + CML) were followed. Seven of 15 (46.7%) LyBC-CML patients developed meningeal leukemia within a median period of 6 months (range 2-11 months), while there was no medullary relapse. Five of these responded well to triple intrathecal therapy. In the ALL Ph + CML patients, in spite of central nervous system (CNS) prophylaxis with IT MTX and 18 Gy cranial radiation, two of five patients (40%) experienced meningeal leukemia, one isolated and the other with medullary relapse. The data confirm that LyBC-CML patients experience a high incidence of meningeal leukemia. The role of CNS prophylaxis is not very clear, but its use may delay development and reduce morbidity due to CNS disease. |
| Databáze: | OpenAIRE |
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