Viable Tumor Tissue Adherent to Needle Applicators after Local Ablation: A Risk Factor for Local Tumor Progression
| Autor: | Arian R. van Erkel, Arjen M. Rijken, Joost Huiskens, Fibo J. W. ten Kate, G. D. Slooter, Joost M. Klaase, Nikol Snoeren, Petrousjka van den Tol, Thomas M. van Gulik, Maarten C. Jansen, Richard van Hillegersberg |
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| Přispěvatelé: | Other departments, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Pathology, Surgery, Faculteit der Geneeskunde, Radiology and nuclear medicine, CCA - Innovative therapy |
| Jazyk: | angličtina |
| Předmět: |
Male
Pathology medicine.medical_specialty Carcinoma Hepatocellular medicine.medical_treatment Catheter ablation Risk Factors Surgical oncology Carcinoma medicine Humans Prospective Studies Risk factor Survival rate Aged Gastrointestinal Oncology business.industry musculoskeletal neural and ocular physiology Liver Neoplasms Prognosis medicine.disease Ablation Survival Rate nervous system Oncology Needles Tumor progression Catheter Ablation Disease Progression Female Surgery Neoplasm Recurrence Local Tomography X-Ray Computed Complication business Follow-Up Studies |
| Zdroj: | Annals of surgical oncology, 18(13), 3702-3710. Springer New York Annals of Surgical Oncology, 18(13), 3702-3710. Springer New York Snoeren, N, Huiskens, J, Rijken, A M, van Hillegersberg, R, van Erkel, A R, Slooter, G D, Klaase, J M, van den Tol, P M, Ten Kate, F J W, Jansen, M C & van Gulik, T M 2011, ' Viable Tumor Tissue Adherent to Needle Applicators after Local Ablation: A Risk Factor for Local Tumor Progression ', Annals of Surgical Oncology, vol. 18, no. 13, pp. 3702-3710 . https://doi.org/10.1245/s10434-011-1762-8 Annals of Surgical Oncology |
| ISSN: | 1068-9265 |
| DOI: | 10.1245/s10434-011-1762-8 |
| Popis: | Background. Local tumor progression (LTP) is a serious complication after local ablation of malignant liver tumors, negatively influencing patient survival. LTP may be the result of incomplete ablation of the treated tumor. In this study, we determined whether viable tumor cells attached to the needle applicator after ablation was associated with LTP and disease-free survival. Methods. In this prospective study, tissue was collected of 96 consecutive patients who underwent local liver ablations for 130 liver malignancies. Cells and tissue attached to the needle applicators were analyzed for viability using glucose-6-phosphate-dehydrogenase staining and autofluorescence intensity levels of H&E stained sections. Patients were followed-up until disease progression. Results. Viable tumor cells were found on the needle applicators after local ablation in 26.7% of patients. The type of needle applicator used, an open approach, and the omission of track ablation were significantly correlated with viable tumor tissue adherent to the needle applicator. The presence of viable cells was an independent predictor of LTP. The attachment of viable cells to the needle applicators was associated with a shorter time to LTP. Conclusions. Viable tumor cells adherent to the needle applicators were found after ablation of 26.7% of patients. An independent risk factor for viable cells adherent to the needle applicators is the omission of track ablation. We recommend using only RFA devices that have track ablation functionality. Adherence of viable tumor cells to the needle applicator after local ablation was an independent risk factor for LTP |
| Databáze: | OpenAIRE |
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