Exosomes Derived from Gold Nanorod Engineered Vascular Endothelial Cells Inhibit Tumor Growth via Disrupting the TGFβ Pathway

Autor: Weiye Zhu, Rui Zhang, Zichang Zhao, Na Zhao, Xiao Gui, Xiao Cui, Ni Shen, Jiawei Zhao, Guangping Gao, Haorui Zhang, Chenyang Huan, Yukun Zhou, Yanjie Li, Jianhua Zhang, Hongyuan Song, Wei Shen
Rok vydání: 2022
Předmět:
Zdroj: Journal of Nanomaterials. 2022:1-11
ISSN: 1687-4129
1687-4110
Popis: Exosomes are nanosized extracellular vesicles which are emerging as novel therapeutic nanoparticles. This paper reports a novel concept of engineering exosomes using nanomaterial inside the vascular endothelial cells (ECs). Gold nanorods (GNRs) could inhibit EC division and internalized GNRs located in endosomes of binucleated ECs. The GNRs could alter the composition of bioactive molecules loaded in exosomes. The engineered EC-derived exosomes could inhibit tumor cell proliferation, migration, and invasion in vitro and suppress tumor growth in vivo. miRNA sequencing showed that the engineered exosomes contained various miRNAs that could disrupt the TGFβ pathway. Further data suggested that the engineered exosomes could suppress the expression of TGF β 1 and TGF β 2, thus inhibiting the activation of SMAD2 and SMAD3. These data highlighted the therapeutic potential of engineering exosomes using nanomaterials.
Databáze: OpenAIRE
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