Age-related changes in the brain antioxidant status: modulation by dietary supplementation of Decalepis hamiltonii and physical exercise
| Autor: | Santosh Anand, Ramachandregowda Sowbhagya, Sindhghatta Kariyappa Anupama, Tekupalli Ravikiran, Dundaiah Bhagyalakshmi |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Aging Antioxidant Clinical chemistry medicine.medical_treatment Clinical Biochemistry Physical exercise Decalepis hamiltonii Antioxidants 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Lipid oxidation Internal medicine Physical Conditioning Animal medicine Animals Rats Wistar Molecular Biology chemistry.chemical_classification biology Superoxide Plant Extracts Brain Cell Biology General Medicine Malondialdehyde biology.organism_classification Rats Apocynaceae 030104 developmental biology Enzyme Endocrinology chemistry 030217 neurology & neurosurgery |
| Zdroj: | Molecular and cellular biochemistry. 419(1-2) |
| ISSN: | 1573-4919 |
| Popis: | The synergistic effects of physical exercise and diet have profound benefits on brain function. The present study was aimed to determine the effects of exercise and Decalepis hamiltonii (Dh) on age-related responses on the antioxidant status in discrete regions of rat brain. Male Wistar albino rats of 4 and 18 months old were orally supplemented with Dh extract and swim trained at 3 % intensity for 30 min/day, 5 days/week, for a period of 30 days. Supplementation of 100 mg Dh aqueous extract/kg body weight and its combination with exercise significantly elevated the antioxidant enzyme activities irrespective of age. Age-related and region-specific changes were observed in superoxide levels, and protein carbonyl and malondialdehyde contents, and were found to be decreased in both trained and supplemented groups. Levels of total thiols, protein, and nonprotein thiols decreased with age and significantly increased in the SW-T(+100 mg) groups. Our results demonstrated that the interactive effects of two treatments enhanced the antioxidant status and decreased the risk of protein and lipid oxidation in the rat brain. |
| Databáze: | OpenAIRE |
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