Human germinal center-associated lymphoma protein expression is associated with improved failure-free survival in Brazilian patients with classical Hodgkin lymphoma
| Autor: | Nelson Spector, Irene Biasoli, Denize Azambuja, Adriana Scheliga, José Carlos Morais, Wolmar Pulcheri, Izidore S. Lossos, Yasodha Natkunam, Luciana Britto |
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| Rok vydání: | 2009 |
| Předmět: |
Oncology
Male Pathology Cancer Research Cohort Studies chemistry.chemical_compound Antineoplastic Combined Chemotherapy Protocols Aged 80 and over Tissue microarray Microfilament Proteins Intracellular Signaling Peptides and Proteins Hematology Middle Aged Prognosis Hodgkin Disease Immunohistochemistry Vinblastine Neoplasm Proteins Dacarbazine Treatment Outcome Female Brazil medicine.drug Adult medicine.medical_specialty Adolescent Bleomycin Article Young Adult Predictive Value of Tests Internal medicine medicine Humans Survival analysis Aged business.industry Germinal center medicine.disease Germinal Center Survival Analysis Lymphoma chemistry ABVD Doxorubicin Tissue Array Analysis business |
| Zdroj: | Leukemia and Lymphoma. :1-7 |
| ISSN: | 1042-8194 |
| Popis: | The human germinal center-associated lymphoma (HGAL) gene has prognostic value in diffuse large B-cell lymphoma, and expression of its cognate protein is germinal center-specific. A previous study had suggested that HGAL protein expression might also be related to the outcome in patients with Hodgkin lymphoma (HL). The aim of this study was to confirm the prognostic impact of HGAL protein expression in an independent, well-characterized cohort of 232 patients with classic HL treated uniformly with doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD). Tissue microarray analysis showed HGAL staining in 188 specimens (81%). Failure-free survival (FFS) was superior in patients with early-stage disease, low-risk IPS, and HGAL-positive patients. The estimated 5-year FFS for HGAL-positive and HGAL-negative patients was 82% and 67%, respectively (p = 0.03). In the multivariate analysis, advanced stage and absence of HGAL staining were independent predictors of a worse FFS. This study confirms and validates recent findings of a correlation between HGAL expression and outcome in classical HL. |
| Databáze: | OpenAIRE |
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