Skeletal troponin I as a marker of exercise-induced muscle damage
| Autor: | Bernd Puschendorf, Erika Artner-Dworzak, Walter Gebert, S. Sorichter, Johannes Mair, Daniel Rama, A. Koller, Charles Calzolari |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Physiology L-Lactate dehydrogenase Muscle damage Running Oxygen Consumption Physiology (medical) Troponin I Medicine Humans Lactic Acid Muscle Skeletal Creatine Kinase Exercise biology L-Lactate Dehydrogenase Myosin Heavy Chains business.industry Myoglobin Anatomy Troponin Kinetics biology.protein Creatine kinase business Biomarkers |
| Zdroj: | Journal of applied physiology (Bethesda, Md. : 1985). 83(4) |
| ISSN: | 8750-7587 |
| Popis: | Sorichter, Stephan, Johannes Mair, Arnold Koller, Walter Gebert, Daniel Rama, Charles Calzolari, Erika Artner-Dworzak, and Bernd Puschendorf. Skeletal troponin I as a marker of exercise-induced muscle damage. J. Appl. Physiol.83(4): 1076–1082, 1997.—The utility of skeletal troponin I (sTnI) as a plasma marker of skeletal muscle damage after exercise was compared against creatine kinase (CK), myoglobin (Mb), and myosin heavy chain (MHC) fragments. These markers were serially measured in normal physical education teacher trainees after four different exercise regimens: 20 min of level or downhill (16% decline) running (intensity: 70% maximal O2uptake), high-force eccentric contractions (70 repetitions), or high-force isokinetic concentric contractions of the quadriceps group (40 repetitions). Eccentrically biased exercise (downhill running and eccentric contractions) promoted greater increases in all parameters. The highest plasma concentration were found after downhill running {median peaks: 309 U/l CK concentration ([CK])}, 466 μg/l Mb concentration ([Mb]), 1,021 μU/l MHC concentration ([MHC]), and 27.3 μg/l sTnI concentration ([sTnI]). Level running produced a moderate response (median peaks: 178 U/l [CK], 98 μg/l [Mb], 501 μU/l [MHC], and 6.6 μg/l [sTnI]), whereas the concentric contraction protocol did not elicit significant changes in any of the markers assayed. sTnI increased and peaked in parallel to CK and stayed elevated (>2.2 μg/l) for at least 1–2 days after exercise. In contrast to MHC, sTnI is an initial, specific marker of exercise-induced muscle injury, which may be partly explained by their different intracellular compartmentation with essentially no (MHC |
| Databáze: | OpenAIRE |
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