Circular RNA 0081146 facilitates the progression of gastric cancer by sponging miR-144 and up-regulating HMGB1
| Autor: | Sheng Hu, Qihua Xu, Bingling Liao, Wei Xia, Ying Zhou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0301 basic medicine chemical and pharmacologic phenomena Bioengineering Apoptosis medicine.disease_cause 01 natural sciences Applied Microbiology and Biotechnology 03 medical and health sciences Mice Downregulation and upregulation Circular RNA Stomach Neoplasms 010608 biotechnology Cell Line Tumor medicine Gene silencing Animals Humans HMGB1 Protein Cell Proliferation Gene knockdown Oncogene Chemistry Cell growth Cancer General Medicine RNA Circular medicine.disease Survival Analysis Up-Regulation Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology Case-Control Studies Cancer research Disease Progression Carcinogenesis Neoplasm Transplantation Biotechnology |
| Zdroj: | Biotechnology letters. 43(4) |
| ISSN: | 1573-6776 |
| Popis: | Recent studies have revealed that circular RNA (circRNA) plays a pivotal role in cancer development. The study aimed to investigate the role of circ_0081146 in gastric cancer (GC). Circ_0081146 was upregulated in GC tissues and cells. Patients with high expression of circ_0081146 had a significantly reduced 5-year overall survival rate. Circ_0081146 knockdown restrained the growth, migration and invasion of GC cells in vitro as well as tumorigenesis in vivo. Circ_0081146 targeted miR-144 and HMGB1 was targeted by miR-144. Circ_0081146 was negatively correlated with miR-144 expression, while positively correlated with HMGB1 expression in GC tissues. Moreover, the inhibitory effect of circ_0081146 knockdown on the progression of GC cells were reversed by silencing miR-144 or HMGB1 overexpression. Mechanically, circ_0081146 increased HMGB1 expression by targeting miR-144. Circ_0081146 functions as an oncogene in GC to promote cell growth, migration and invasion via modulating the miR-144/HMGB1 axis. |
| Databáze: | OpenAIRE |
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