Transcription factor Klf9 controls bile acid reabsorption and enterohepatic circulation in mice via promoting intestinal Asbt expression

Autor:	Shuang, Liu, Man, Liu, Meng-Lin, Zhang, Cui-Zhe, Wang, Yin-Liang, Zhang, Yu-Jie, Zhang, Chun-Yuan, Du, Su-Fang, Sheng, Wei, Wang, Ya-Tong, Fan, Jia-Ni, Song, Jin-Can, Huang, Yue-Yao, Feng, Wei, Qiao, Jin-Long, Huang, Yu-Hui, Li, Lu, Zhou, Jun, Zhang, Yong-Sheng, Chang
Rok vydání:	2022
Předmět:	Pharmacology Symporters Kruppel-Like Transcription Factors Organic Anion Transporters Sodium-Dependent General Medicine Bile Acids and Salts Intestines Mice Inbred C57BL Mice Liver Enterohepatic Circulation Animals Pharmacology (medical) Transcription Factors
Zdroj:	Acta Pharmacologica Sinica. 43:2362-2372
ISSN:	1745-7254 1671-4083
Popis:	Bile acid (BA) homeostasis is regulated by the extensive cross-talk between liver and intestine. Many bile-acid-activated signaling pathways have become attractive therapeutic targets for the treatment of metabolic disorders. In this study we investigated the regulatory mechanisms of BA in the intestine. We showed that the BA levels in the gallbladder and faeces were significantly increased, whereas serum BA levels decreased in systemic Krüppel-like factor 9 (Klf9) deficiency (Klf9
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f208f8e9520748f71d4c51d7af1249b7 https://doi.org/10.1038/s41401-021-00850-x Zobrazit plný text záznamu Full text from SpringerLink