COVID-19 and cardiac arrhythmias
| Autor: | Saman Nazarian, David S. Frankel, John R. Bullinga, Christopher M. Domenico, Ramanan Kumareswaram, Srinivas Denduluri, Anjali Bhatla, Robert D. Schaller, Francis E. Marchlinski, Eric J. Oh, Pasquale Santangeli, Matthew C. Hyman, David J. Callans, Juwann Moss, Jeffrey Arkles, Fermin C. Garcia, Srinath Adusumalli, Michael P. Riley, David Lin, Sanjay Dixit, Ann Tierney, Rajat Deo, Andrew E. Epstein, Gregory E. Supple, George L. Anesi, Michael Mayer, Anwar A. Chahal, Benjamin S. Abella |
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| Rok vydání: | 2020 |
| Předmět: |
Male
cardiac arrest 030204 cardiovascular system & hematology Ventricular tachycardia law.invention Cohort Studies 0302 clinical medicine Risk Factors law Hospital Mortality 030212 general & internal medicine COVID-19 Coronavirus disease 2019 education.field_of_study Incidence Atrial fibrillation Middle Aged ICU intensive care unit Intensive care unit Hospitalization cardiovascular system Cardiology Female Coronavirus Infections Cardiology and Cardiovascular Medicine Cohort study Adult medicine.medical_specialty AF atrial fibrillation Pneumonia Viral Population arrhythmia SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 Article Betacoronavirus 03 medical and health sciences Physiology (medical) Internal medicine medicine Humans education Pandemics BNP B-type natriuretic peptide Aged SARS-CoV-2 business.industry COVID-19 Arrhythmias Cardiac Odds ratio medicine.disease mortality Heart Arrest NSVT nonsustained ventricular tachycardia Heart failure business Kidney disease |
| Zdroj: | Heart Rhythm |
| ISSN: | 1547-5271 |
| Popis: | Background Early studies suggest that coronavirus disease 2019 (COVID-19) is associated with a high incidence of cardiac arrhythmias. SARS-CoV-2 infection may cause injury to cardiac myocytes and increase arrhythmia risk. Objective To evaluate the risk of cardiac arrest and arrhythmias including incident atrial fibrillation (AF), bradyarrhythmias, and nonsustained ventricular tachycardia (NSVT) in a large urban population hospitalized for COVID-19. We also evaluated correlations between the presence of these arrhythmias and mortality. Methods We reviewed the characteristics of all COVID-19 patients admitted to our center over a 9-week period. Throughout hospitalization, we evaluated the incidence of cardiac arrests, arrhythmias and in-patient mortality. We also used logistic regression to evaluate age, sex, race, body mass index, prevalent cardiovascular disease, diabetes, hypertension, kidney disease and ICU status as potential risk factors for each arrhythmia. Results Among 700 patients (mean age 50±18 years, 45% men, 71% African American, and 11% received ICU care), there were 9 cardiac arrests, 25 incident AF events, 9 clinically significant bradyarrhythmias, and 10 NSVTs. All cardiac arrests occurred among patients admitted to the ICU. In addition, admission to the ICU was associated with incident AF (OR 4.68 [95% CI 1.66 – 13.18]) and NSVT (OR 8.92 [95% CI 1.73 – 46.06]) after multivariable adjustment. Also, age and incident AF (OR 1.05 [95% CI 1.02 – 1.09]); and prevalent heart failure and bradyarrhythmias (OR 9.75 [95% CI 1.95 – 48.65]) were independently associated. Only cardiac arrests were associated with acute, in-hospital mortality. Conclusion Cardiac arrests and arrhythmias are likely the consequence of systemic illness and not solely the direct effects of COVID-19 infection. Graphical abstract |
| Databáze: | OpenAIRE |
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