Microglia activation in multiple sclerosis black holes predicts outcome in progressive patients: An in vivo [(11)C](R)-PK11195-PET pilot study
| Autor: | Kit Wu, Paul Su, Richard Nicholas, Marios Politis, Paola Piccini, Richard Reynolds, Paolo Giannetti, Omar Malik, Federico Turkheimer, Shiva Keihaninejad |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Pathology Pilot Projects lcsh:RC321-571 Multiple sclerosis Myelin Predictive Value of Tests Internal medicine Humans Medicine Neurodegeneration lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry PK11195-PET Expanded Disability Status Scale medicine.diagnostic_test Black holes business.industry Magnetic resonance imaging Middle Aged Isoquinolines medicine.disease Amides Magnetic Resonance Imaging Pathophysiology medicine.anatomical_structure Neurology Positron emission tomography Positron-Emission Tomography Predictive value of tests Disease Progression Female Microglia business |
| Zdroj: | Neurobiology of Disease, Vol 65, Iss, Pp 203-210 (2014) |
| ISSN: | 0969-9961 |
| Popis: | The pathophysiological correlates and the contribution to persisting disability of hypointense T1-weighted MRI lesions, black holes (BH), in multiple sclerosis (MS) are still unclear. In order to study the in vivo functional correlates of this MRI finding, we used 11C-PK11195 PET (PK-PET) to investigate changes in microglial activity. Ten relapsing and 9 progressive MS subjects had a PK-PET scan and a MRI scan alongside a full clinical assessment, including the expanded disability status scale (EDSS) for evaluation of disability. We studied the PK binding potential of the specifically bound radioligand relative to the non-displaceable radioligand in tissue (BPND) in T1 BHs. Out of a total of 1242 BHs identified, 947 were PK enhancing. The PKBPND was correlated with the EDSS (r = 0.818; p |
| Databáze: | OpenAIRE |
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