Macroautophagy is repressed during mitosis - seeing is believing
| Autor: | Richard I. Odle, Simon J. Cook |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Autophagosome Cell division Genome integrity Autophagy-Related Proteins CDK1 (cyclin dependent kinase 1) omegasome mTORC1 Biology RPTOR/RAPTOR (regulatory associated protein of MTOR complex 1) 03 medical and health sciences ATG13 (autophagy related 13) Macroautophagy Autophagy Animals Autophagy-Related Protein-1 Homolog Humans Molecular Biology Mitosis Omegasome mitosis Cyclin-dependent kinase 1 030102 biochemistry & molecular biology MTORC1 (MTOR complex 1) ULK1 (unc-51 like autophagy activating kinase 1) Autophagosomes Cell Biology Autophagic Punctum Cell biology 030104 developmental biology MTOR (mechanistic target of rapamycin kinase) |
| Zdroj: | Autophagy |
| ISSN: | 1554-8635 |
| Popis: | For the last two decades there has been wide ranging debate about the status of macroautophagy during mitosis. Because metazoan cells undergo an “open” mitosis in which the nuclear envelope breaks down, it has been proposed that macroautophagy must be inhibited to maintain genome integrity. While many studies have agreed that the number of autophagosomes is greatly reduced in cells undergoing mitosis, there has been no consensus on whether this reflects decreased autophagosome synthesis or increased autophagosome degradation. Reviewing the literature we were concerned that many studies relied too heavily on autophagy assays that were simply not appropriate for a relatively brief event such as mitosis. Using highly dynamic omegasome markers we have recently shown unequivocally that autophagosome synthesis is repressed at the onset of mitosis and is restored once cell division is complete. This is accomplished by CDK1, the master regulator of mitosis, taking over the function of MTORC1, to ensure autophagy is repressed during mitosis. |
| Databáze: | OpenAIRE |
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