Naturally acquired HPV antibodies against subsequent homotypic infection: A large-scale prospective cohort study
| Autor: | Jun Zhang, Xingmei Yao, Xiao-Hui Liu, Ya Zheng, Zhijie Lin, Ting Wu, Wen Chen, Qin-Jing Pan, Mingqiang Li, Xun Zhang, Li Zhang, Wei Sheng, Mingzhu Li, Yuemei Hu, Huirong Pan, Fangfang Hu, Yue Huang, Yuqian Zhao, Qing Li, Li-hui Wei, Jun Zhao, Shang-Ying Hu, Ying Hong, Yingying Su, Ningshao Xia, Chao Zhao, Bizhen Lin, Fang-Hui Zhao, Huifang Xu, You-Lin Qiao, Shoujie Huang |
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| Rok vydání: | 2021 |
| Předmět: |
Pseudovirion
Internal Medicine medicine Prospective cohort study Cervical cancer biology Proportional hazards model business.industry Health Policy Hazard ratio Public Health Environmental and Occupational Health Obstetrics and Gynecology medicine.disease Confidence interval Psychiatry and Mental health Infectious Diseases Pediatrics Perinatology and Child Health Cohort Immunology biology.protein Public aspects of medicine RA1-1270 Geriatrics and Gerontology Antibody business Research Paper |
| Zdroj: | The Lancet Regional Health: Western Pacific The Lancet Regional Health. Western Pacific, Vol 13, Iss, Pp 100196-(2021) |
| ISSN: | 2666-6065 |
| Popis: | Summary Background Although recent studies have suggested that naturally acquired Human papillomavirus (HPV) antibodies are partly protective against subsequent homotypic infection, the extent of protection remains indecisive. Here, we evaluate the protective effect of neutralizing and IgG antibodies simultaneously. Methods In a cohort of 3634 women aged 18-45 years from the control arm of a phase III trial of the HPV-16/18 bivalent vaccine, participants were tested for neutralizing antibodies by pseudovirion-based neutralization assay (PBNA) and IgG antibodies by enzyme-linked immunosorbent assay (ELISA) at baseline. HPV-16/18 incident and persistent infections were identified using cervical specimens periodically collected during the 5·5 years of follow-up. The protective effects of HPV-16/18 neutralizing and IgG antibodies against homotypic infection were assessed using a Cox proportional hazard model. Findings For the persistent infection (PI) endpoints of HPV-16/18 lasting for over 6/12 months, a prevalence of type-specific neutralizing antibodies was highly protective (6-month PI: hazard ratio (HR) = 0·16, 95% confidence interval (CI): 0·04, 0·65; 12-month PI: HR = 0·23, 95% CI: 0·06, 0·94), whereas a prevalence of IgG antibodies was associated with minor and non-significant protection (6-month PI: HR = 0·66, 95% CI: 0·40, 1·09; 12-month PI: HR = 0·66, 95% CI: 0·36, 1·20). After increasing the cut-off value to the median IgG level, the risk of 6-month PI was significantly lower in seropositive vs seronegative women (HR = 0·38, 95% CI: 0·18, 0·83). Interpretation Naturally acquired antibodies are associated with a substantially reduced risk of subsequent homotypic infection. Funding NSFC; The Fujian Province Health Education Joint Research Project; Xiamen Science and Technology Major Project; CIFMS; and Xiamen Innovax. |
| Databáze: | OpenAIRE |
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