Retrospective comparison of Adderall and methylphenidate in the treatment of attention deficit hyperactivity disorder
| Autor: | Stephen Grcevich, William A. Rowane, Shannon Sullivan-Hurst, Beth Marcellino |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Time Factors medicine.medical_treatment medicine Attention deficit hyperactivity disorder Humans Pharmacology (medical) Dosing Psychiatry Child Retrospective Studies Psychiatric Status Rating Scales Retrospective review business.industry Methylphenidate Amphetamines Retrospective cohort study medicine.disease Treatment period Stimulant Psychiatry and Mental health Attention Deficit Disorder with Hyperactivity Pediatrics Perinatology and Child Health Central Nervous System Stimulants Female business Dosing Frequency medicine.drug |
| Zdroj: | Journal of child and adolescent psychopharmacology. 11(1) |
| ISSN: | 1044-5463 |
| Popis: | Methylphenidate is the most frequently prescribed stimulant medication for the treatment of attention deficit hyperactivity disorder (ADHD). However, the short duration of action of methylphenidate requires that patients take multiple daily doses for optimal efficacy. Recent studies suggest that Adderall, a psychostimulant indicated for the treatment of ADHD, may provide an efficacious, less frequently dosed alternative to methylphenidate. This retrospective review compares the efficacy, safety, dosing frequency, and medication switch rates of Adderall with methylphenidate in children and adolescents with ADHD treated in a private, outpatient psychiatric clinic. Of the evaluable patients, 54 received Adderall, and 75 received methylphenidate. No statistically significant differences were noted between Adderall and methylphenidate in efficacy or safety parameters. Fewer patients receiving Adderall required twice daily, thrice daily, or in-school dosing than those receiving methylphenidate (p < 0.001). During the initial 6-month treatment period, patients treated with Adderall were less likely to switch medications than those receiving methylphenidate (p = 0.0002). In this analysis, Adderall and methylphenidate provided comparable efficacy and safety in children and adolescents with ADHD. The use of Adderall allowed patients to extend their dosing interval and reduced the need for in-school dosing, a measure that may substantially influence compliance. |
| Databáze: | OpenAIRE |
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