Glycine max Merr. leaf extract possesses anti-oxidant properties, decreases inflammatory mediator production in murine macrophages, and inhibits growth, migration, and adhesion in human cancer cells
| Autor: | Youngeun Kwak, Jihyeung Ju |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification 030109 nutrition & dietetics Flavonoid Pharmacology Applied Microbiology and Biotechnology Article In vitro Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Biochemistry In vivo 030220 oncology & carcinogenesis Glycine medicine Gallic acid Prostaglandin E2 Quercetin Food Science Biotechnology medicine.drug |
| Zdroj: | Food Science and Biotechnology. 26:245-253 |
| ISSN: | 2092-6456 1226-7708 |
| Popis: | The present study aimed to investigate the in vitro anti-oxidant, anti-inflammatory, and anticancer properties of the ethanol extract of soybean (Glycine max Merr.) leaves (SLE). The total polyphenol and flavonoid levels were 142.0±14.0mg gallic acid equivalent/g and 104.9±2.0 mg quercetin equivalent/g, respectively. The radical scavenging activity and ferric-reducing anti-oxidant power of SLE at the concentrations of 125–500 μg/mL were 5–61%. In lipopolysaccharide-treated RAW 264.7 macrophages, treatment with SLE at concentrations of 62.5–500 μg/mL dose-dependently decreased the production of nitric oxide and prostaglandin E2. In both HCT116 human colon cancer cells and H1299 human lung cancer cells, treatment with SLE inhibited the growth and anchorage-independent colony formation. SLE was also effective in inhibiting the migration of H1299 cells and the adhesion of both HCT116 and H1299 cells. These results suggest that SLE exerts anti-oxidant, antiinflammatory, and anti-cancer activities in vitro. It needs to be determined whether similar effects are reproduced in vivo. |
| Databáze: | OpenAIRE |
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