PET Radiopharmaceuticals for Specific Bacteria Imaging: A Systematic Review
Autor: | Rika Horvat, Sveva Auletta, Filippo Galli, Michela Varani, Alberto Signore, Søren Hess |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
medicine.medical_specialty
lcsh:Medicine Diagnostic accuracy Review Single-photon emission computed tomography 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Nuclear medicine imaging Medicine Medical physics bacteria nuclear medicine imaging medicine.diagnostic_test business.industry Quality assessment lcsh:R PET infection Index test General Medicine Quality of evidence Systematic review Positron emission tomography 030220 oncology & carcinogenesis business |
Zdroj: | Journal of Clinical Medicine Auletta, S, Varani, M, Horvat, R, Galli, F, Signore, A & Hess, S 2019, ' PET Radiopharmaceuticals for Specific Bacteria Imaging : A Systematic Review ', Journal of Clinical Medicine, vol. 8, no. 2, 197 . https://doi.org/10.3390/jcm8020197 Journal of Clinical Medicine, Vol 8, Iss 2, p 197 (2019) |
ISSN: | 2077-0383 |
Popis: | BACKGROUND: Bacterial infections are still one of the main factors associated with mortality worldwide. Many radiopharmaceuticals were developed for bacterial imaging, both with single photon emission computed tomography (SPECT) and positron emission tomography (PET) isotopes. This review focuses on PET radiopharmaceuticals, performing a systematic literature review of published studies between 2005 and 2018.METHODS: A systematic review of published studies between 2005 and 2018 was performed. A team of reviewers independently screened for eligible studies. Because of differences between studies, we pooled the data where possible, otherwise, we described separately. Quality of evidence was assessed by Quality Assessment of Diagnostic Accuracy Studies (QUADAS) approach.RESULTS: Eligible papers included 35 published studies. Because of the heterogeneity of animal models and bacterial strains, we classified studies in relation to the type of bacterium: Gram-positive, Gram-negative, Gram-positive and negative, others.CONCLUSIONS: Results highlighted the availability of many promising PET radiopharmaceuticals for bacterial imaging, despite some bias related to animal selection and index test, but few have been translated to human subjects. Results showed a lack of standardized infection models and experimental settings. |
Databáze: | OpenAIRE |
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