Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera
| Autor: | Bin Liu, Yuanli Song, Xiufeng Zhang, Ping-ping Shen, Hongmei Wang, Yang Liu, Lan-fen Wang, Li-hua Nie |
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| Rok vydání: | 2006 |
| Předmět: |
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Molecular Magnetic Resonance Spectroscopy Antioxidant Stereochemistry medicine.medical_treatment Radical Clinical Biochemistry Molecular Conformation Pharmaceutical Science Pharmacognosy Crystallography X-Ray Biochemistry Antioxidants Aloe vera chemistry.chemical_compound Coumarins Superoxides Drug Discovery medicine Immunologic Factors Aloe Molecular Biology chemistry.chemical_classification biology Chemistry Superoxide Organic Chemistry Stereoisomerism Biological activity General Medicine Macrophage Activation Reference Standards biology.organism_classification Respiratory burst Macrophages Peritoneal Molecular Medicine Two-dimensional nuclear magnetic resonance spectroscopy Lactone |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 16:949-953 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2005.10.096 |
| Popis: | Two new dihydrocoumarin derivatives, compounds 1 and 2, were isolated from Aloe vera. Their structures were determined by X-ray crystallographic diffraction analysis and extensive 1D, 2D NMR spectroscopic data. Both of them evidently showed antioxidant activity against superoxide and hydroxyl radicals. Only 1 obviously exhibited immunomodulatory activity in relation to increasing the phagocytic activity and stimulating the production of superoxide anions in the oxygen respiratory burst of rat peritoneal macrophages. |
| Databáze: | OpenAIRE |
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