Hypercoagulable state in a hypobaric, hypoxic environment causes non-bacterial thrombotic endocarditis in rats
| Autor: | Fumiko Tajima, Keisaku Sugiyama, Hideo Maruta, Toshiaki Kawai, Kuniaki Nakanishi, Chikao Torikata, Yasuko Nakata, Minoru Suzuki, Hiroshi Osada |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Pathology Polycythaemia Myocardial Infarction Growth Altitude Sickness Kidney Pathology and Forensic Medicine Internal medicine Coagulopathy medicine Animals Thromboplastin Endocarditis Platelet Rats Wistar Thrombus business.industry Blood Coagulation Disorders Hypoxia (medical) medicine.disease Thrombosis Blood Coagulation Factors Rats Microscopy Electron Atmospheric Pressure Endocrinology Infarction Mitral Valve medicine.symptom business |
| Zdroj: | The Journal of Pathology. 181:338-346 |
| ISSN: | 1096-9896 0022-3417 |
| DOI: | 10.1002/(sici)1096-9896(199703)181:3<338::aid-path773>3.0.co;2-4 |
| Popis: | High-altitude hypoxia causes polycythaemia and a hypercoagulable state in humans and animals. This study examines the effects of a hypobaric, hypoxic environment (HHE) on the blood coagulation system in rats. A total of 170 male Wistar rats were housed in a chamber at the equivalent of 5500 m in altitude for 1–12 weeks. After 2 weeks of exposure to HHE, platelet counts decreased significantly; after 4 weeks, the prothrombin and activated partial thromboplastin times were significantly prolonged, compared with those of control rats. In addition, individual coagulation factors (VII, IX, X, XI, and XII) were significantly decreased at 8 weeks (P |
| Databáze: | OpenAIRE |
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