Predominant tuberculosis spoligotypes, Delhi, India
| Autor: | Jyoti Arora, Nalin Rastogi, Pande Jn, Urvashi B. Singh, Naga Suresh, Sanjeev Sinha, Hema Pant, Pradeep Seth, Christophe Sola, Sushma Singh, N.Vijaya Bhanu, Ram Charan Aggarwal |
|---|---|
| Předmět: |
Microbiology (medical)
Adult DNA Bacterial Male Tuberculosis Adolescent Genotype Epidemiology Hiv epidemic prevalence lcsh:Medicine Beijing genotype India Disease Biology direct repeat locus Disease cluster lcsh:Infectious and parasitic diseases Mycobacterium tuberculosis spoligo database Screening method medicine Cluster Analysis Humans lcsh:RC109-216 cluster Phylogeny Repetitive Sequences Nucleic Acid spoligotyping Transmission (medicine) dendrogram lcsh:R Dispatch transmission spoligotype Middle Aged biology.organism_classification medicine.disease Virology Bacterial Typing Techniques Infectious Diseases CAS-I family Female geographic locations Demography |
| Zdroj: | Scopus-Elsevier Emerging Infectious Diseases Emerging Infectious Diseases, Vol 10, Iss 6, Pp 1138-1142 (2004) |
| Popis: | One hundred five Mycobacterium tuberculosis clinical isolates from the Delhi area were typed by spoligotyping; 45 patterns were identified. Comparison with an international spoligotype database showed type 26, Delhi type (22%), type 54 (12%), and type 1, Beijing type (8%), as the most common. Eighteen spoligotypes did not match any existing database pattern. I ndia accounts for 30% of tuberculosis (TB) cases worldwide. Each year, this disease develops in approximately 2 million people in India. Approximately 0.5 million people die, a figure likely to increase with emergence of multidrug-resistant tuberculosis (MDR-TB) and the HIV epidemic (1). Delhi alone has an annual risk for infection of 2.4% (state TB officer, Delhi, pers. comm.). Traditional methods for tracing transmission of TB are imprecise and ineffective in controlling the disease. The impact of control programs is often difficult to assess in high-incidence areas, where infection and disease patterns are highly heterogeneous. This difficulty can be overcome by an alternative approach in which molecular strain-typing techniques are used. Spoligotyping detects the presence and absence of nonrepetitive unique spacer sequences (36–41 bp in length) in the direct repeat region of Mycobacterium tuberculosis. Its utility as an initial screening method is well documented (2–4). The aim of our study was to identify predominant spoligotypes with an international designation responsible for transmission and prevalence of TB in Delhi. The spoligotypes obtained were compared with an international spoligodatabase, spolDB3.0 (5,6). The Study |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|