Transcatheter arterial chemoembolization followed by surgical resection for hepatocellular carcinoma: a focus on its controversies and screening of patients most likely to benefit
| Autor: | Zhan-Qi Wei, Yue-Wei Zhang, Ning-Ning Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Carcinoma Hepatocellular Hepatocellular carcinoma medicine.medical_treatment Review Article Adjuvant therapy medicine Carcinoma Hepatectomy Humans Combined Modality Therapy Chemoembolization Therapeutic Transcatheter arterial chemoembolization Survival rate business.industry Liver Neoplasms General Medicine medicine.disease Surgery Regimen Surgical resection Medicine Neoplasm Recurrence Local business |
| Zdroj: | Chinese Medical Journal, Vol 134, Iss 19, Pp 2275-2286 (2021) Chinese Medical Journal |
| ISSN: | 2542-5641 0366-6999 |
| DOI: | 10.1097/CM9.0000000000001767 |
| Popis: | Surgical resection (SR) is recommended as a radical procedure in the treatment of hepatocellular carcinoma (HCC). However, postoperative recurrence negatively affects the long-term efficacy of SR, and preoperative adjuvant therapy has therefore become a research hotspot. Some clinicians adopt transcatheter arterial chemoembolization (TACE) as a preoperative adjuvant therapy in patients undergoing SR to increase the resection rate, reduce tumor recurrence, and improve the prognosis. However, the findings of the most relevant studies remain controversial. Some studies have confirmed that preoperative TACE cannot improve the long-term survival rate of patients with HCC and might even negatively affect the resection rate. Which factors influence the efficacy of preoperative TACE combined with SR is a topic worthy of investigation. In this review, existing clinical studies were analyzed with a particular focus on several topics: screening of the subgroups of patients most likely to benefit from preoperative TACE, exploration of the optimal treatment regimen of preoperative TACE, and determination of the extent of tumor necrosis as the deciding prognostic factor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|