NADPH oxidase activation is required for migration by LIGHT in human monocytes
| Autor: | Sun-Dong Park, Won-Hwan Park, Sook-Kyoung Heo, Hyun-Jeong Yun |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
CCR1
Tumor Necrosis Factor Ligand Superfamily Member 14 CCR2 Receptors CCR2 Receptors CCR1 Biophysics Biology medicine.disease_cause Biochemistry Monocytes Chemokine receptor Mediator NF-KappaB Inhibitor alpha Cell Movement medicine Humans Phosphorylation Molecular Biology chemistry.chemical_classification Reactive oxygen species NADPH oxidase Tumor Necrosis Factor-alpha Interleukin-8 NADPH Oxidases Cell Biology Recombinant Proteins Cell biology Enzyme Activation Herpes simplex virus chemistry biology.protein I-kappa B Proteins Reactive Oxygen Species |
| Zdroj: | Biochemical and Biophysical Research Communications. 371:834-840 |
| ISSN: | 0006-291X |
| Popis: | Homologous to lymphotoxins, shows inducible expression, and competes with herpes simplex virus (HSV) glycoprotein D (gD) for herpes virus entry mediator (HVEM; TR2) (LIGHT), a ligand of herpes virus entry mediator (HVEM), increased reactive oxygen species (ROS) and enhanced the destruction of bacteria in human monocytes. In this study, rhLIGHT was found to increase the expression of the chemokine receptors, chemokine receptor 1 (CCR1) and CCR2, as well as to accelerate the migration activity of human monocytes. Additionally, rhLIGHT was found to increase ROS via NADPH oxidase p47phox phosphorylation, which was found to be required for LIGHT-induced NF-κB activation, CCR1 and CCR2 expression, migration and IL-8 and TNF-α production. Taken together, these results indicate that NADPH oxidase activation is required for rhLIGHT-induced migration in human monocytes. |
| Databáze: | OpenAIRE |
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