Effect of a Metal Mixture in Diet On the Toxicokinetics and Toxicity of Cadmium, Mercury and Manganese in Rats
| Autor: | Krista Kostial, J.F. Stara, I. Rabar, D. Kello, Teodora Maljkovi, Maja Blanu |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
0301 basic medicine Aging Health Toxicology and Mutagenesis chemistry.chemical_element 010501 environmental sciences Toxicology 01 natural sciences 03 medical and health sciences Animal science Oral administration Lactation medicine Animals Toxicokinetics Drug Interactions 0105 earth and related environmental sciences Manganese Cadmium 030102 biochemistry & molecular biology Manganese Poisoning Public Health Environmental and Occupational Health Rats Inbred Strains Mercury Acute toxicity Animals Suckling Diet Rats Bioavailability Mercury (element) medicine.anatomical_structure chemistry Metals Toxicity Female |
| Zdroj: | Toxicology and Industrial Health. 5:685-698 |
| ISSN: | 1477-0393 0748-2337 |
| DOI: | 10.1177/074823378900500509 |
| Popis: | The purpose of this work was to determine whether a metal mix ture added to diet influences the toxicokinetics and toxicity of some elements. The metal mixture (MM) used in these experiments was ash (slag) from a coal gasification plant. The effect of this mixture (5 percent in diet) on the toxicokinetic and on the acute or subchronic toxicity of Cd, Hg, Mn was determined in rats of different ages. Rats were exposed for five weeks in toxicokinetic and six weeks in acute tox icity experiments. Sucklings were exposed through their mothers, which received the MM in diet over the pregnancy and lactation period. In toxicokinetic studies, half of the animals additionally received Cd, Hg or Mn (100, 50 or 2000 ppm, respectively) in drinking water. In subchronic experiments, six-week-old albino rats of both sexes were given MM in the diet and Cd, Hg or Mn in drinking water for 16 weeks. In toxicokinetic studies, 115mCd,203 Hg or 54Mn were administered orally or intraperitoneally to mothers and pups. Exposure to MM had no effect on the absorption, retention and organ distribution of these elements determined six days after radioisotope administra tion. In acute toxicity studies, exposure to MM in diet had no effect on LD50 values obtained eight days after oral administration of Cd, Hg or Mn to rats of different ages. In subchronic experi ments, the effect of individual metals (Cd, Hg or Mn) was similar in animals with and without simultaneous exposure to the metal mixture (only a slight potentiation of a few health-effect parameters of cadmium was noticed in some animals). It is concluded that oral exposure to MM in the diet had almost no effect on the toxicokinetics and toxicity of Cd, Hg and Mn. This could be explained by the low level or low bioavailability of ele ments from MM, by the metal-metal interaction within the mixture or by the choice of health effect indicators determined. These results are presented as one of the potential approaches for study ing the health effect of a metal mixture as occurring in the environment. |
| Databáze: | OpenAIRE |
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