Lack of Evidence for Cancer Due to Use of Metronidazole
| Autor: | Malcolm B. Dockerty, Leonard T. Kurland, Kenneth L. Noller, Beard Cm, William M. O'Fallon |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
medicine.medical_specialty Lung Neoplasms Adolescent medicine.drug_class Antibiotics Uterine Cervical Neoplasms Breast Neoplasms Gastroenterology Metronidazole Neoplasms Internal medicine medicine Carcinoma Humans Cervix Carcinogen Aged Gynecology Trichomoniasis business.industry Cancer General Medicine Middle Aged medicine.disease medicine.anatomical_structure Vagina Female Trichomonas Vaginitis business medicine.drug |
| Zdroj: | New England Journal of Medicine. 301:519-522 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm197909063011003 |
| Popis: | Experimental studies have shown that metronidazole is carcinogenic in rodents and mutagenic in bacteria. In 771 women given metronidazole for the treatment of vaginal trichomoniasis, more cancers developed than had been expected after exclusion of carcinoma of one uterine cervix (observed, 24 cases; expected on the basis of the Connecticut Tumor Registry, 21.7; expected on the basis of the Third National Cancer Survey, 18.4). However, the excess was not statistically significant (P>0.05). The observed and expected numbers of breast-cancer cases were the same, but four lung-cancer cases were observed, whereas 0.6 would have been expected. This finding is confounded by the fact that all four lung cancers developed in women who were smokers. Overall, we observed no appreciable increase in cases of cancer. (N Engl J Med 301:519–522, 1979) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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