Preclinical Restenosis Models: Challenges and Successes
| Autor: | Robert S. Schwartz, Arturo G. Touchard |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Percutaneous Swine medicine.medical_treatment Drug Evaluation Preclinical Coronary Artery Disease 030204 cardiovascular system & hematology Toxicology Pathology and Forensic Medicine Coronary Restenosis Coronary artery disease 03 medical and health sciences Dogs 0302 clinical medicine Restenosis Internal medicine medicine Animals Molecular Biology business.industry Coronary Thrombosis Percutaneous coronary intervention Stent Cell Biology equipment and supplies medicine.disease Coronary Vessels Thrombosis Rats Coronary arteries Disease Models Animal 030104 developmental biology medicine.anatomical_structure Cardiology Stents Rabbits Tunica Intima business Artery |
| Zdroj: | Toxicologic Pathology. 34:11-18 |
| ISSN: | 1533-1601 0192-6233 |
| Popis: | Coronary artery disease remains a major problem for Western societies. The advent of percutaneous interventions, including stents has brought clinical care to a new level of efficacy, yet problems remain. Restenosis following stenting in human coronary arteries appears at last to be yielding to therapeutic strategies, especially drug eluting stents. Because therapeutic percutaneous coronary intervention is widely dominated by the intracoronary stent, restenosis therapies must include the stented coronary artery. Animal models and in particular the porcine coronary model seem to represent the human coronary artery reaction to stenting. It mimics several clinical conditions including thrombosis and neointimal formation. A key question in the era of intravascular technologies is how well this and other models can predict clinical events. This paper discusses the models and their application. |
| Databáze: | OpenAIRE |
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