Complete Genome Sequence of the MRSA Isolate HC1335 from ST239 Lineage Displaying a Truncated AgrC Histidine Kinase Receptor
| Autor: | Guilherme Loss de Morais, Ana Tereza Ribeiro de Vasconcelos, Nicholas Costa Barroso Lima, Fabienne Antunes Ferreira, Bruno de Souza Scramignon Costa, Maiana O. C. Costa, Ana Maria Nunes Botelho, Cristiana Ossaille Beltrame, Luiz Gonzaga Paula de Almeida, Marisa Fabiana Nicolás, Rangel C. Souza, Agnes Marie Sá Figueiredo |
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| Rok vydání: | 2016 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
0301 basic medicine Lineage (genetic) IS256 insertion 030106 microbiology Virulence agrC dysfunction Biology 03 medical and health sciences Bacterial Proteins Genetics Pathogen Gene Ecology Evolution Behavior and Systematics Transposase Whole genome sequencing ST239 lineage complete genome sequence Histidine kinase Genetic Variation biochemical phenomena metabolism and nutrition Mutagenesis Insertional Quorum sensing DNA Transposable Elements Genetic Fitness Protein Kinases Genome Bacterial Research Article |
| Zdroj: | Genome Biology and Evolution |
| ISSN: | 1759-6653 |
| DOI: | 10.1093/gbe/evw225 |
| Popis: | Methicillin-resistant Staphylococcus aureus (MRSA) is still one of the most important hospital pathogen globally. The multiresistant isolates of the ST239-SCCmecIII lineage are spread over large geographic regions, colonizing and infecting hospital patients in virtually all continents. The balance between fitness (adaptability) and virulence potential is likely to represent an important issue in the clonal shift dynamics leading the success of some specific MRSA clones over another. The accessory gene regulator (agr) is the master quorum sensing system of staphylococci playing a role in the global regulation of key virulence factors. Consequently, agr inactivation in S. aureus may represent a significant mechanism of genetic variability in the adaptation of this healthcare-associated pathogen. We report here the complete genome sequence of the methicillin-resistant S. aureus, isolate HC1335, a variant of the ST239 lineage, which presents a natural insertion of an IS256 transposase element in the agrC gene encoding AgrC histidine kinase receptor. |
| Databáze: | OpenAIRE |
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