Occult HBV infection status among chronic hepatitis C and hemodialysis patients in Northeastern Egypt: regional and national overview
| Autor: | Atef Shehata, Nader Nemr, Mohamed Mandour, Rania Kishk, Nashaat Hawass, Dahlia I. Badran |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
HBsAg Prevalence Gastroenterology Polymerase Chain Reaction Blood serum Medicine Child biology virus diseases Hepatitis C Hepatitis B Middle Aged Infectious Diseases Hemodialysis HCV Female Egypt Antibody Viral hepatitis Microbiology (medical) Adult medicine.medical_specialty Hepatitis B virus lcsh:Arctic medicine. Tropical medicine Adolescent lcsh:RC955-962 Enzyme-Linked Immunosorbent Assay Young Adult Renal Dialysis Internal medicine Humans Hepatitis B Antibodies Aged Hepatitis B Surface Antigens business.industry Occult hepatitis B Hepatitis C Chronic medicine.disease Virology digestive system diseases DNA Viral biology.protein Kidney Failure Chronic Parasitology Liver function business Anti-HBc |
| Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical, Vol 48, Iss 3, Pp 258-264 (2015) Revista da Sociedade Brasileira de Medicina Tropical, Volume: 48, Issue: 3, Pages: 258-264, Published: JUN 2015 Revista da Sociedade Brasileira de Medicina Tropical v.48 n.3 2015 Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
| ISSN: | 1678-9849 |
| Popis: | INTRODUCTION: Occult hepatitis B infection (OBI) is considered to be one of the major risks for patients suffering from end-stage renal disease (ESRD) on regular hemodialysis (HD) and patients with chronic hepatitis C virus (HCV) infection. This study compared the prevalence of OBI among these two high-risk groups in the Suez Canal region, Northeastern Egypt, to obtain a better national overview of the magnitude of OBI in this region. METHODS: Serum samples were collected from 165 HD patients and 210 chronic HCV-infected patients. Anti-HCV antibody, hepatitis B surface antigen (HBsAg), total hepatitis B core (anti-HBc) antibody, and hepatitis B surface antibody (anti-HBs) were detected by enzyme-linked immunosorbent assay (ELISA). HCV RNA was detected using a quantitative real-time RT-PCR assay, and HBV was detected using a nested PCR. RESULTS: All patients were negative for HBsAg. A total of 49.1% and 25.2% of the patients in the HD and HCV groups, respectively, were anti-HBc-positive. In addition, more anti-HBs-positive patients were detected in the HD group compared to the HCV group (52.1% and 11.4%, respectively). Three cases were positive for HBV DNA in the HD group, while eighteen positive cases were detected in the HCV group. Both study groups showed significant differences in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level as well as anti-HBc, anti-HBs and HBV-DNA positivity. CONCLUSIONS: OBI was more prevalent among chronic HCV patients than HD patients in the Suez Canal region, Egypt, with rates of 8.5% and 1.8%, respectively. However, more precise assessment of this infection requires regular patient follow-up using HBV DNA detection methods. |
| Databáze: | OpenAIRE |
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