Targeting active cancer cells with smart bullets
| Autor: | Sylvain Martel |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
cancer translational research
robotic functionalities 0209 industrial biotechnology targeting active cancer cells Computer science Pharmaceutical Science Nanotechnology Review 02 engineering and technology magnetic fields Drug Delivery Systems 020901 industrial engineering & automation nonsystemic therapeutic delivery Neoplasms tumor hypoxic zones Humans clinical MRI scanner high therapeutic index magnetotactic bacteria 021001 nanoscience & nanotechnology 3. Good health vascular navigation smart delivery agents Delivery system 0210 nano-technology Magic bullet Engineering principles |
| Zdroj: | Therapeutic Delivery |
| ISSN: | 2041-6008 2041-5990 |
| DOI: | 10.4155/tde-2016-0088 |
| Popis: | Paul Ehrlich's ‘magic bullet’ concept has stimulated research for therapeutic agents with the capability to go straight to their intended targets. The ‘magic bullet’ concept is still considered the ultimate approach to maximize the therapeutic effects of a given therapeutic agent without affecting nontargeted tissues. But so far, there has never been a therapeutic agent or a delivery system that goes straight to the target in the body, and no approach has provided anything better than just a few percents of the total administered dose reaching the intended target sites. But engineering principles can transform systematically circulating vectors that so far were based primarily on physical characteristics and biochemical principles alone, as smart therapeutic agents with the required propulsion–navigation–homing capabilities to enable them to go straight to their intended targets. |
| Databáze: | OpenAIRE |
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