Clinical features and histological patterns of lupus nephritis in a single center of South India
| Autor: | Mahesh Eshwarappa, Lakshminarayanan Mekala, M Gireesh Siddaiah, K Gurudev Channabasappa, Vijaya Mysorekar, Clement Wilfred Devadass |
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| Rok vydání: | 2016 |
| Předmět: |
Nephrology
Adult Male medicine.medical_specialty Pathology Anti-nuclear antibody Adolescent Population 030232 urology & nephrology Lupus nephritis lcsh:Medicine India 030230 surgery Single Center Kidney Gastroenterology 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine medicine Humans Lupus Erythematosus Systemic education Child Retrospective Studies education.field_of_study Lupus erythematosus medicine.diagnostic_test business.industry lcsh:R General Medicine Middle Aged medicine.disease Lupus Nephritis Renal pathology Female Renal biopsy business |
| Zdroj: | Saudi Journal of Kidney Diseases and Transplantation, Vol 27, Iss 6, Pp 1224-1230 (2016) |
| ISSN: | 1319-2442 |
| Popis: | Renal involvement occurs in up to 60% of patients with systemic lupus erythematosus (SLE) and signifies a poor prognosis. The class of lupus nephritis (LN), determined on renal biopsy evaluation, guides the therapeutic management and has prognostic connotations. Our aim is to determine the clinicolaboratory features and histopathological patterns of LN at presentation in our local (South Indian) population. The study was conducted in a tertiary care hospital in South India between 2009 and 2014 on SLE patients with clinical evidence of LN. The renal biopsies were examined by light and immunofluorescence microscopy and were classified according to the International Society of Nephrology/Renal Pathology Society Classification of LN. A total of 46 patients were included, with age range of 12-60 years and a female to male ratio of 8.2:1. Arthritis, dermatological manifestations, and fever occurred, respectively, in 43.5%, 39.1%, and 30.4% of the cases. Class IV LN was present in 17 (37.1%), Class III LN in ten (21.7%), Class II LN in nine (19.5%), Class V LN in eight (17.4%), Class I LN in one (2.2%), and Class VI LN in one (2.2%) patients. Antinuclear antibody (ANA) and dsDNA positivity were present, respectively, in 82.6% and 65.2% of the patients. The most common pattern of LN was Class IV LN followed by Class III LN. Relatively higher proportions of ANA and anti-dsDNA positivity were present in proliferative LN, and there was a high frequency of arthritis at presentation in our LN patients. |
| Databáze: | OpenAIRE |
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