Arterial pressure lability is improved by sodium-glucose cotransporter 2 inhibitor in streptozotocin-induced diabetic rats
| Autor: | Tomoko Yoshikawa, Takuya Kishi, Ko Takesue, Kenji Sunagawa, Keisuke Shinohara, Toyoshi Inoguchi, Noriyuki Sonoda, Yoshitaka Hirooka, Risa Shibata, Hiroyuki Tsutsui |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Physiology medicine.medical_treatment White coat hypertension 030204 cardiovascular system & hematology Baroreflex Prehypertension Streptozocin Diabetes Mellitus Experimental Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Heart Rate Diabetes mellitus Internal medicine Internal Medicine medicine Animals Arterial Pressure 030212 general & internal medicine Sodium-Glucose Transporter 2 Inhibitors Lability business.industry Insulin medicine.disease Streptozotocin Rats Blood pressure Endocrinology Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Hypertension research : official journal of the Japanese Society of Hypertension. 40(7) |
| ISSN: | 1348-4214 |
| Popis: | To prevent cardiovascular events in patients with diabetes mellitus (DM), it is essential to reduce arterial pressure (AP). Sodium-glucose cotransporter 2 inhibitor (SGLT2i) prevents cardiovascular events via the depressor response in patients with DM. In the present study, we examined whether SGLT2i ameliorates AP lability in DM rats. Ten-week-old male Sprague–Dawley rats were administered a single intravenous injection of streptozotocin (50 mg kg−1) and were divided into three groups treated with low-dose SGLT2i, vehicle (VEH) or subcutaneously implanted insulin pellets (SGLT2i, VEH and Insulin group, respectively) for 14 days. SGLT2i reduced blood glucose, but its effect was lower than that of insulin. The telemetered mean AP at the end of the experiment did not differ among the SGLT2i, Insulin and VEH groups (83±7 vs. 98±9 vs. 90±8 mm Hg, respectively, n=5 for each). The standard deviation of AP as the index of lability was significantly smaller during the active period in the SGLT2i group than in the VEH group (5.6±0.5 vs. 7.0±0.7 mm Hg, n=5 for each, P |
| Databáze: | OpenAIRE |
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