6-(4-Benzylpiperazin-1-yl)benzodioxanes as selective ligands at cloned primate dopamine D4 receptors

Autor:	Jan W. F. Wasley, Kevin J. Hodgetts, Jennifer Tran, Andrew Thurkauf, Robbin Brodbeck, Andrzej Kieltyka
Rok vydání:	2001
Předmět:	Primates Stereochemistry Clinical Biochemistry Drug Evaluation Preclinical Pharmaceutical Science CHO Cells Ligands Biochemistry Chemical synthesis Piperazines Dioxanes Structure-Activity Relationship Dopamine receptor D1 Dopamine Cricetinae Drug Discovery medicine Animals Structure–activity relationship Receptor Molecular Biology Bicyclic molecule Receptors Dopamine D2 Chemistry Receptors Dopamine D4 Organic Chemistry Antagonist Recombinant Proteins Dopamine D2 Receptor Antagonists Guanosine 5'-O-(3-Thiotriphosphate) Dopamine receptor Dopamine Antagonists Molecular Medicine medicine.drug
Zdroj:	Bioorganic & Medicinal Chemistry. 9:3207-3213
ISSN:	0968-0896
DOI:	10.1016/s0968-0896(01)00226-7
Popis:	A series of novel 6-(4-benzylpiperazin-1-yl)benzodioxanes were prepared and screened at selected dopamine receptor subtypes. 6-(4-[4-Chlorobenzyl]piperazin-1-yl)benzodioxane (2d) had high affinity and selectivity for the D(4) dopamine receptor subtype and was identified as a D(4) antagonist via its attenuation of dopamine-induced GTPgamma(35)S binding at the D(4) receptor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ed98e2c5f3546ebaaa185570b3e4e6 https://doi.org/10.1016/s0968-0896(01)00226-7 Zobrazit plný text záznamu Full Text from ScienceDirect