TGFβ as a gatekeeper of BMP action in the developing growth plate
| Autor: | Weiguang Wang, Karen M. Lyons, Diana Rigueur |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Histology Physiology 1.1 Normal biological development and functioning Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Smad Proteins SMAD Bone morphogenetic protein Medical and Health Sciences Article 03 medical and health sciences Endocrinology & Metabolism 0302 clinical medicine Engineering Underpinning research Transforming Growth Factor beta TGF beta Animals Humans BMP Growth Plate Receptor Effector Chemistry Biological Sciences Receptor interaction Cell biology Crosstalk (biology) 030104 developmental biology Cartilage TGF β Bone Morphogenetic Proteins Growth plate Signal transduction Intracellular Transforming growth factor Signal Transduction |
| Zdroj: | Bone |
| Popis: | The ligands that comprise the Transforming Growth Factor β superfamily highly govern the development of the embryonic growth plate. Members of this superfamily activate canonical TGFβ and/or BMP (Bone Morphogenetic Protein) signaling pathways. How these pathways interact with one another is an area of active investigation. These two signaling pathways have been described to negatively regulate one another through crosstalk involving Smad proteins, the primary intracellular effectors of canonical signaling. More recently, a mechanism for regulation of the BMP pathway through TGFβ and BMP receptor interactions has been described. Here in this review, we demonstrate examples of how TGFβ is a gatekeeper of BMP action in the developing growth plate at both the receptor and transcriptional levels. |
| Databáze: | OpenAIRE |
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