Lysophosphatidic acid induces increased BACE1 expression and Aβ formation
| Autor: | Yunzhou Dong, Jing Shi, Xuemin Xu, Mei-Zhen Cui |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Gene isoform
Oxidized LDL medicine.medical_specialty β-Secretase CREB Article Pathogenesis Mice 03 medical and health sciences chemistry.chemical_compound Beta-amyloid peptide 0302 clinical medicine Downregulation and upregulation Alzheimer Disease Cell Line Tumor Internal medicine Lysophosphatidic acid medicine Amyloid precursor protein Animals Aspartic Acid Endopeptidases Humans Molecular Biology Protein kinase C 030304 developmental biology 0303 health sciences Amyloid beta-Peptides biology Alzheimer's disease Up-Regulation Cell biology Lipoproteins LDL Endocrinology chemistry Cell culture biology.protein Molecular Medicine lipids (amino acids peptides and proteins) Amyloid Precursor Protein Secretases Lysophospholipids 030217 neurology & neurosurgery |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (1):29-38 |
| ISSN: | 0925-4439 |
| DOI: | 10.1016/j.bbadis.2012.09.010 |
| Popis: | The abnormal production and accumulation of β-amyloid peptide (Aβ), which is produced from amyloid precursor protein (APP) by the sequential actions of β-secretase and γ-secretase, are thought to be the initial causative events in the development of Alzheimer's disease (AD). Accumulating evidence suggests that vascular factors play an important role in the pathogenesis of AD. Specifically, studies have suggested that one vascular factor in particular, oxidized low density lipoprotein (oxLDL), may play an important role in regulating Aβ formation in AD. However, the mechanism by which oxLDL modulates Aβ formation remains elusive. In this study, we report several new findings that provide biochemical evidence suggesting that the cardiovascular risk factor oxLDL may contribute to Alzheimer's disease by increasing Aβ production. First, we found that lysophosphatidic acid (LPA), the most bioactive component of oxLDL induces increased production of Aβ. Second, our data strongly indicate that LPA induces increased Aβ production via upregulating β-secretase expression. Third, our data strongly support the notion that different isoforms of protein kinase C (PKC) may play different roles in regulating APP processing. Specifically, most PKC members, such as PKCα, PKCβ, and PKCε, are implicated in regulating α-secretase-mediated APP processing; however, PKCδ, a member of the novel PKC subfamily, is involved in LPA-induced upregulation of β-secretase expression and Aβ production. These findings may contribute to a better understanding of the mechanisms by which the cardiovascular risk factor oxLDL is involved in Alzheimer's disease. |
| Databáze: | OpenAIRE |
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