Investigations into an outbreak of tuberculosis in a flock of sheep in contact with tuberculous cattle
| Autor: | E. C. Wilson, J. M. Pollock, R. A. Skuce, F. E. Malone |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Veterinary medicine
Tuberculosis Positive reaction Sheep Diseases Biology Disease Outbreaks Lesion Interferon-gamma medicine Disease Transmission Infectious Animals Typing Mycobacterium bovis Sheep Outbreak General Medicine Intradermal Tests medicine.disease biology.organism_classification Variable number tandem repeat Dairying Cattle Female Flock medicine.symptom Ireland Tuberculosis Bovine |
| Zdroj: | Journal of veterinary medicine. B, Infectious diseases and veterinary public health. 50(10) |
| ISSN: | 0931-1793 |
| Popis: | Tuberculosis, associated with Mycobacterium bovis infection, occurs infrequently in sheep. A sheep flock, which was potentially exposed to a high level of infection from in-contact tuberculous cattle, was examined for evidence of infection. Six sheep that had given a positive reaction to the comparative intradermal tuberculin test were examined post mortem. Tuberculous lesions were present in four of these sheep. Lesion morphology and distribution in the sheep was similar to that in cattle. M. bovis was cultured from the lesions and the isolates were strain typed by spoligotyping and variable number of tandem repeats (VNTR) typing. Tuberculin-reacting sheep also reacted positively to an assay for in vitro release of interferon-gamma. This paper describes the first report of an outbreak of tuberculosis in sheep in either Britain or Ireland. The report describes immunology and pathology findings and, using molecular typing techniques, suggests that the sheep had been infected from in-contact cattle. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text