Glucose-6-Phosphate Dehydrogenase Deficiency is Associated with Cardiovascular Disease in U.S. Military Centers
| Autor: | Charles J. Wyatt, A. David Mangelsdorff, Forest S. Kim, Seungho Kang, Fred K. Weigel, John E. Thomas |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Dehydrogenase Disease Glucosephosphate Dehydrogenase 030204 cardiovascular system & hematology Hospitals Military medicine.disease_cause Military medicine 03 medical and health sciences 0302 clinical medicine Internal medicine hemic and lymphatic diseases Odds Ratio Prevalence medicine Humans 030212 general & internal medicine Clinical Investigation Mass screening Retrospective Studies U s military business.industry medicine.disease United States Hemolysis Cross-Sectional Studies Glucosephosphate Dehydrogenase Deficiency Military Personnel Endocrinology Cardiovascular Diseases Cardiology and Cardiovascular Medicine business Oxidative stress Glucose-6-phosphate dehydrogenase deficiency |
| Popis: | Glucose-6-phosphate dehydrogenase (G6PD) protects erythrocytes from oxidative stress and hemolysis; G6PD deficiency is the most prevalent enzymopathy. The United States military routinely performs tests to prevent exposing G6PD-deficient personnel to antimalarial drugs that might cause life-threatening hemolytic reactions. In addition, G6PD is a key determinant of vascular function, and its deficiency can lead to impaired nitric oxide production and greater vascular oxidant stress—precursors to atherosclerosis and cardiovascular disease. Using military medical records, we performed a retrospective, cross-sectional study to investigate whether deficient G6PD levels are associated with a higher prevalence of cardiovascular disease than are normal levels, and, if so, whether the relationship is independent of accepted cardiovascular risk factors. We analyzed the medical records of 737 individuals who had deficient G6PD levels and 16,601 who had normal levels. Everyone had been screened at U.S. military medical centers from August 2004 through December 2007. We evaluated our dependent variable (composite cardiovascular disease) at the individual level, and performed binary logistic regression of our independent variable (G6PD status) and control variables (modifiable cardiovascular risk factors). The adjusted odds ratio of 1.396 (95% CI, 1.044–1.867; P Early intervention may reduce the incidence of cardiovascular disease in military personnel and civilians who have deficient G6DP levels. |
| Databáze: | OpenAIRE |
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