Progress of the COVID-19 vaccine effort: viruses, vaccines and variants versus efficacy, effectiveness and escape
| Autor: | Benjamin F. Pierce, Ziyin Wang, Katie E. Flight, John S. Tregoning, Sophie L. Higham |
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| Rok vydání: | 2021 |
| Předmět: |
Vaccines
Clinical Trials as Topic History 2019-20 coronavirus outbreak medicine.medical_specialty COVID-19 Vaccines Coronavirus disease 2019 (COVID-19) SARS-CoV-2 business.industry Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Adult population Severe disease World Health Organization Vaccine efficacy Health Services Accessibility Computer Science Applications Education Progress Pandemic Humans Medicine business Intensive care medicine |
| Zdroj: | Nature Reviews. Immunology |
| ISSN: | 1474-1741 1474-1733 |
| DOI: | 10.1038/s41577-021-00592-1 |
| Popis: | Where 2020 saw the development and testing of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at an unprecedented pace, the first half of 2021 has seen vaccine rollout in many countries. In this Progress article, we provide a snapshot of ongoing vaccine efficacy studies, as well as real-world data on vaccine effectiveness and the impact of virus variants of concern. Where they have been deployed in a high proportion of the adult population, the currently approved vaccines have been extremely effective in preventing COVID-19, particularly severe disease. Nonetheless, there are still significant challenges in ensuring equitable vaccine access around the globe and lessons that can be learned for controlling this pandemic and for the next pandemic. This Progress article provides an update on the COVID-19 vaccine effort in the light of ongoing vaccine efficacy studies and real-world data on vaccine effectiveness, including the impact of virus variants of concern and challenges for global deployment. |
| Databáze: | OpenAIRE |
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