Update of the human parvovirus B19 biology
| Autor: | A Servant-Delmas, F Morinet |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Blood transfusion Genotype Blood Safety medicine.medical_treatment 030106 microbiology Clinical Biochemistry Viremia Biology Virus Replication Parvoviridae Infections 03 medical and health sciences Parvovirus B19 Human medicine Humans Clinical significance Infectious dose Biochemistry (medical) Genetic Variation Transfusion Reaction Hematology medicine.disease Virology Cell Hypoxia 030104 developmental biology Viral replication Erythema Infectiosum DNA Viral Immunology Viral load |
| Zdroj: | Transfusion Clinique et Biologique. 23:5-12 |
| ISSN: | 1246-7820 |
| DOI: | 10.1016/j.tracli.2015.11.006 |
| Popis: | Since its discovery, the human parvovirus B19 (B19V) has been associated with many clinical situations in addition to the prototype clinical manifestations, i.e. erythema infectiosum and erythroblastopenia crisis. The clinical significance of the viral B19V DNA persistence in sera after acute infection remains largely unknown. Such data may constitute a new clinical entity and is discussed in this manuscript. In 2002, despite the genetic diversity among B19V viruses has been reported to be very low, the description of markedly distinct sequences showed a new organization into three genotypes. The most recent common ancestor for B19V genotypes was estimated at early 1800s. B19V replication is enhanced by hypoxia and this might to explain the high viral load detected by quantitative PCR in the sera of infected patients. The minimum infectious dose necessary to transmit B19V infection by the transfusion of labile blood products remains unclear. At the opposite, the US Food and Drug Administration proposed a limit of 10(4)IU/mL of viral DNA in plasma pools used for the production of plasma derivatives. Recently, a new human parvovirus (PARV4) has been discovered. The consequences on blood transfusion of this blood-borne agent and its pathogenicity are still unknown. |
| Databáze: | OpenAIRE |
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