Effect of preservation solutions for static cold storage on kidney transplantation outcomes: A National Registry Study
Autor: | Marie-Alice Macher, Camille Legeai, Louise Durand, Olivier Bastien, Emilie Savoye |
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Rok vydání: | 2019 |
Předmět: |
medicine.medical_specialty
Adenosine Allopurinol Organ Preservation Solutions Urology Cold storage Renal function 030230 surgery Logistic regression Kidney 03 medical and health sciences 0302 clinical medicine Raffinose Immunology and Allergy Medicine Humans Insulin Pharmacology (medical) Viaspan Registries Kidney transplantation Transplantation business.industry Odds ratio Organ Preservation medicine.disease Glutathione Kidney Transplantation Confidence interval France business |
Zdroj: | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsREFERENCES. 20(12) |
ISSN: | 1600-6143 |
Popis: | This study aimed to evaluate how 5 preservation solutions for static cold storage affected kidney transplant outcomes. It included all first single kidney transplants during 2010-2014 from donations after brain death in the French national transplant registry, excluding preemptive transplants and transplants of kidneys preserved with a hypothermic perfusion machine. The effects of each preservation solution on delayed graft function (DGF) and 1-year transplant failure were evaluated with hierarchical multivariable logistic regression models. The study finally included 7640 transplanted kidneys: 3473 (45.5%) preserved with Institut Georges Lopez-1 solution (IGL-1), 773 (10.1%) with University of Wisconsin solution, 731 (9.6%) with Solution de Conservation des Organes et Tissus (SCOT, organ and tissue preservation solution), 2215 (29.0%) with Celsior, and 448 (5.9%) with histidine-tryptophan-ketoglutarate. Primary nonfunction rates did not differ by solution. After adjustment for donor, recipient, and transplant characteristics, the DGF risk was significantly lower with IGL-1 than with all other solutions (odds ratio [OR] 0.55, 95% confidence interval [CI] 0.48-0.64). Conversely, SCOT was associated with a DGF risk significantly higher than the other solutions (OR 2.69, 95% CI 2.21-3.27) and triple that of IGL-1 (OR 3.37, 95% CI 2.72-4.16). One year after transplantation, the transplant failure rate did not differ significantly by preservation solution. The difference between the groups for 1-year mean creatinine clearance was not clinically relevant. |
Databáze: | OpenAIRE |
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