Comparative trial of single-dose versus twice-daily sisomicin in bacteriuric patients
| Autor: | Jean-Marie Prevost, Jean Klastersky, F. Meunier-Carpentier, Didier Daneau, Michel Gerard |
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| Rok vydání: | 1977 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Bacteriuria Urology Renal function Microbial Sensitivity Tests Drug Administration Schedule law.invention Randomized controlled trial law medicine Humans Pharmacology (medical) Aged Pharmacology Clinical Trials as Topic business.industry Comparative trial Middle Aged medicine.disease Anti-Bacterial Agents Clinical trial Sisomicin Urinary Tract Infections Urologic disease Female Intramuscular injection business medicine.drug |
| Zdroj: | Journal of clinical pharmacology. 17(8-9) |
| ISSN: | 0091-2700 |
| Popis: | Sisomicin was administered as a single daily intramuscular injection (160 mg) or as two daily injections (80 mg) to 50 patients with bacteriuria superimposed on chronic urologic diseases in a randomized controlled fashion. The administration of two daily doses was significantly more effective (P less than 0.01) in achieving cure than the injection of a single daily dose. The renal function, as expressed by creatinine clearance, became impaired significantly more often (P less than 0.05) in the patients receiving the single daily dose of sisomicin. |
| Databáze: | OpenAIRE |
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