Functional Magnetic Resonance Imaging Study of Regional Brain Activation During Implicit Sequence Learning in Obsessive–Compulsive Disorder
| Autor: | Brian Martis, Sabine Wilhelm, Christopher I. Wright, Michelle M. Wedig, Lisa M. Shin, Scott L. Rauch, Katherine McMullin, Paul A. Cannistraro |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Recruitment Neurophysiological Serial reaction time Obsessive-Compulsive Disorder Caudate nucleus Hippocampus behavioral disciplines and activities Cohort Studies Neural Pathways mental disorders Reaction Time medicine Humans Learning Biological Psychiatry Cerebral Cortex medicine.diagnostic_test Brain medicine.disease Magnetic Resonance Imaging Implicit learning Neostriatum Functional imaging Frontal lobe Female Orbitofrontal cortex Psychology Functional magnetic resonance imaging Neuroscience Psychomotor Performance Anxiety disorder |
| Zdroj: | Biological Psychiatry. 61:330-336 |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/j.biopsych.2005.12.012 |
| Popis: | Background Corticostriatal circuitry has been implicated in the pathophysiology of obsessive–compulsive disorder (OCD). The serial reaction time (SRT) task, a paradigm that tests implicit sequence learning, has been used with imaging to probe striatal function. Initial studies have indicated that OCD patients exhibit deficient striatal activation and aberrant hippocampal recruitment compared with healthy control (HC) subjects. Here, we used the SRT and functional magnetic resonance imaging (fMRI) to replicate prior results in a larger sample and to test for relationships between regional activation and OCD symptom dimensions. Methods Using SPM99, fMRI-SRT data from 12 OCD and 12 matched HC subjects were analyzed. Symptom dimensions followed a four-factor model scored on a 0- to 10-point scale. Results For the implicit learning versus random contrast, group by condition interactions revealed aberrant recruitment within the hippocampus as well as orbitofrontal cortex (OCD > HC) but no striatal group differences. However, an inverse correlation was found between striatal activation and specific symptom factors. Conclusions These results replicate previous smaller studies showing aberrant hippocampal recruitment in OCD during SRT performance. Although findings of deficient striatal activation in OCD were not replicated, correlation results suggest that this inconsistency may be attributable to differences among OCD symptom dimensions. |
| Databáze: | OpenAIRE |
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