Effects of intermittent and continuous calorie restriction on body weight and metabolism over 50 wk: a randomized controlled trial
| Autor: | Diana Nabers, Hans-Ulrich Kauczor, Tobias Nonnenmacher, Ruth Schübel, Christopher L. Schlett, Cornelia M. Ulrich, Johanna Nattenmüller, Theron Johnson, Mirja E. Graf, Rudolf Kaaks, Oyunbileg von Stackelberg, Tilman Kühn, Disorn Sookthai, Romy Kirsten, Mario Kratz, Lena Riedl |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Diet Reducing Calorie restriction Medicine (miscellaneous) Physiology Adipose tissue 030209 endocrinology & metabolism Overweight Body Mass Index law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Weight loss law Weight Loss Intermittent fasting medicine Humans Obesity Aged Caloric Restriction 030109 nutrition & dietetics Nutrition and Dietetics business.industry Body Weight Middle Aged medicine.disease Adipose Tissue Female medicine.symptom Energy Intake business Body mass index |
| Zdroj: | The American Journal of Clinical Nutrition. 108:933-945 |
| ISSN: | 0002-9165 |
| Popis: | Background Although preliminary evidence suggests that intermittent calorie restriction (ICR) exerts stronger effects on metabolic parameters, which may link obesity and major chronic diseases, compared with continuous calorie restriction (CCR), there is a lack of well-powered intervention studies. Objective We conducted a randomized controlled trial to test whether ICR, operationalized as the "5:2 diet," has stronger effects on adipose tissue gene expression, anthropometric and body composition measures, and circulating metabolic biomarkers than CCR and a control regimen. Design One hundred and fifty overweight and obese nonsmokers [body mass index (kg/m2) ≥25 to |
| Databáze: | OpenAIRE |
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