Effects of treatment with hydroxychloroquine and azithromycin on the index of cardiac electrophysiological balance in patients with COVID-19: A retrospective cohort study
| Autor: | Hasan Akkoc, Mehmet Zülkif Karahan, Eşref Araç, Mehmet Özel, Ramazan Yiğit, Songül Araç |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Index (economics) Coronavirus disease 2019 (COVID-19) business.industry Retrospective cohort study Hydroxychloroquine Azithromycin COVID-19 Hydroxychloroquine Azithromycin ECG iCEB Tp-e interval Acil Tıp Internal medicine medicine Emergency Medicine In patient business Balance (ability) medicine.drug |
| Zdroj: | Volume: 5, Issue: 5 412-416 Journal of Surgery and Medicine |
| ISSN: | 2602-2079 |
| Popis: | Background/Aim: The common cardiac toxicities of hydroxychloroquine (HCQ) and azithromycin (AZ) are not well defined in COVID-19 patients. Index of cardiac electrophysiological balance (iCEB) is used as a novel risk marker for drug-induced arrhythmias. The purpose of this study was to evaluate ventricular repolarization using iCEB and other conventional ECG parameters such as the end of electrocardiographic T wave (Tp-e) interval, Tp-e/QT ratio, and Tp-e/ heart rate-corrected QT (QTc) ratio in COVID-19 patients treated with HCQ and AZ.Methods: This retrospective study enrolled 164 patients diagnosed with COVID-19 pneumonia in the Emergency Department (ED) and then transferred to the ward or the intensive care unit in April 2020. Results: A total of 164 patients with a mean age of 47 (18) years (range: 18-97 years) included 83 (50.6%) females. There were 38 and 126 patients in Groups HTQ and HTQ+AZ, respectively. On the 5th day of hospitalization, all patients’ heart rates were significantly lower (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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